HOXD3

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq]

Full Name

homeobox D3

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Anterior/posterior pattern specification Source: UniProtKB
Cartilage development Source: UniProtKB
Cell-matrix adhesion Source: UniProtKB
Embryonic skeletal system morphogenesis Source: UniProtKB
Notch signaling pathway Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Thyroid gland development Source: UniProtKB
Transcription, DNA-templated Source: UniProtKB

Cellular Location

Nucleus