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Mouse Anti-HRH1 Recombinant Antibody (CBFYH-1965) (CBMAB-H0499-FY)

This product is mouse antibody that recognizes HRH1. The antibody CBFYH-1965 can be used for immunoassay techniques such as: FC.
See all HRH1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1965
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Histamine Receptor H1
Introduction
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Entrez Gene ID
UniProt ID
Alternative Names
Histamine Receptor H1; HH1R; H1R; Histamine Receptor, Subclass H1; Histamine H1 Receptor; HisH1; H1-R
Function
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Biological Process
Cellular response to histamine Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Eosinophil chemotaxis Source: InterPro
G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Inflammatory response Source: ProtInc
Inositol phosphate-mediated signaling Source: BHF-UCL
Memory Source: Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Positive regulation of inositol trisphosphate biosynthetic process Source: BHF-UCL
Positive regulation of vasoconstriction Source: InterPro
Regulation of synaptic plasticity Source: Ensembl
Regulation of vascular permeability Source: InterPro
Visual learning Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-29
Helical: 30-52
Cytoplasmic: 53-62
Helical: 63-83
Extracellular: 84-101
Helical: 102-123
Cytoplasmic: 124-143
Helical: 144-164
Extracellular: 165-189
Helical: 190-210
Cytoplasmic: 211-416
Helical: 417-438
Extracellular: 439-450
Helical: 451-470
Cytoplasmic: 471-487
PTM
Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation.

Park, C., Lee, J. W., Kim, K., Seen, D. S., Jeong, J. Y., & Huh, W. K. (2023). Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration. Scientific Reports, 13(1), 1894.

Li, H., Xiao, Y., Li, Q., Yao, J., Yuan, X., Zhang, Y., ... & Yu, D. (2022). The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer cell, 40(1), 36-52.

Mo, S., Guo, J., Ye, T., Zhang, X., Zeng, J., Xu, Y., ... & Chen, X. (2022). Mycobacterium tuberculosis utilizes host histamine receptor H1 to modulate reactive oxygen species production and phagosome maturation via the p38MAPK-NOX2 Axis. MBio, 13(5), e02004-22.

Chen, W., Liu, P., Liu, D., Huang, H., Feng, X., Fang, F., ... & Hu, Y. (2022). Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells. Nature Communications, 13(1), 6796.

Ding, Y. F., Lin, Y. W., Chiu, W. K., Lin, C. W., Yang, Y. C., Chang, L. C., ... & Chien, M. H. (2022). Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of oral squamous cell carcinoma. Aging (Albany NY), 14(10), 4500.

Bai, Z., Ai, J., & Wei, X. (2022). Histamine and histamine receptor H1 (HRH1) axis: new target for enhancing immunotherapy response. Molecular Biomedicine, 3(1), 11.

Li, J., Chen, W., Peng, C., Zhu, W., Liu, Z., Zhang, W., ... & Chen, X. (2020). Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria. The Pharmacogenomics Journal, 20(1), 87-93.

Deshetty, U. M., Tamatam, A., Bhattacharjee, M., Perumal, E., Natarajan, G., & Khanum, F. (2020). Ameliorative effect of hesperidin against motion sickness by modulating histamine and histamine H1 receptor expression. Neurochemical Research, 45, 371-384.

Suzuki, Y., Ogasawara, T., Tanaka, Y., Takeda, H., Sawasaki, T., Mogi, M., ... & Maeyama, K. (2018). Functional G-protein-coupled receptor (GPCR) synthesis: the pharmacological analysis of human histamine H1 receptor (HRH1) synthesized by a wheat germ cell-free protein synthesis system combined with asolectin glycerosomes. Frontiers in Pharmacology, 9, 38.

Tiwari, A. K., Zhang, D., Pouget, J. G., Zai, C. C., Chowdhury, N. I., Brandl, E. J., ... & Müller, D. J. (2018). Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain. The World Journal of Biological Psychiatry, 19(sup3), S97-S105.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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