HRH1

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

Histamine Receptor H1

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

Cellular response to histamine Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Eosinophil chemotaxis Source: InterPro
G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Inflammatory response Source: ProtInc
Inositol phosphate-mediated signaling Source: BHF-UCL
Memory Source: Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Positive regulation of inositol trisphosphate biosynthetic process Source: BHF-UCL
Positive regulation of vasoconstriction Source: InterPro
Regulation of synaptic plasticity Source: Ensembl
Regulation of vascular permeability Source: InterPro
Visual learning Source: Ensembl

Cell membrane

Extracellular: 1-29
Helical: 30-52
Cytoplasmic: 53-62
Helical: 63-83
Extracellular: 84-101
Helical: 102-123
Cytoplasmic: 124-143
Helical: 144-164
Extracellular: 165-189
Helical: 190-210
Cytoplasmic: 211-416
Helical: 417-438
Extracellular: 439-450
Helical: 451-470
Cytoplasmic: 471-487

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation.