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Mouse Anti-HS3ST2 Recombinant Antibody (5D5) (CBMAB-A4097-LY)

The product is antibody recognizes HS3ST2. The antibody 5D5 immunoassay techniques such as: WB, ELISA.
See all HS3ST2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5D5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HS3ST2 (NP_006034, 268 a.a. ~ 367 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Introduction
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq]
Entrez Gene ID
9956
UniProt ID
Q9Y278
Alternative Names
30ST2; 3OST2
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:9988768).

Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS (PubMed:9988768).

Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:9988768).
Biological Process
Glycosaminoglycan biosynthetic process Source: Reactome
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-19
Helical: 20-39
Lumenal: 40-367

Zhang, F., Li, F., & Lu, J. (2023). microRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2. Cellular Signalling, 102, 110532.

Huynh, M. B., Rebergue, N., Merrick, H., Gomez-Henao, W., Jospin, E., Biard, D. S. F., & Papy-Garcia, D. (2022). HS3ST2 expression induces the cell autonomous aggregation of tau. Scientific Reports, 12(1), 10850.

Li, L., Gao, Y., Han, Z., Du, J., Yu, Y., Zhang, N., ... & Wang, M. (2022). Modified risk of breast cancer by dietary factors and HS3ST2 methylation.

Gao, G., Shi, X., & Shen, J. (2021). HS3ST2 and its related molecules as potential biomarkers for predicting lymph node metastasis in patients with colorectal cancer. OncoTargets and therapy, 3881-3894.

Teixeira, F. C., Vijaya Kumar, A., Kumar Katakam, S., Cocola, C., Pelucchi, P., Graf, M., ... & Götte, M. (2020). The heparan sulfate sulfotransferases HS2ST1 and HS3ST2 are novel regulators of breast cancer stem-cell properties. Frontiers in Cell and Developmental Biology, 8, 559554.

Eyvazi, S., Khamaneh, A. M., Tarhriz, V., Bandehpour, M., Hejazi, M. S., Sadat, A. T. E., & Sepehri, B. (2020). CpG islands methylation analysis of CDH11, EphA5, and HS3ST2 genes in gastric adenocarcinoma patients. Journal of gastrointestinal cancer, 51, 579-583.

Meng, L., Li, M., Gao, Z., Ren, H., Chen, J., Liu, X., ... & Yang, L. (2019). Possible role of hsa-miR-194-5p, via regulation of HS3ST2, in the pathogenesis of atopic dermatitis in children. European Journal of Dermatology, 29, 603-613.

Delos, M., Foulquier, F., Hellec, C., Vicogne, D., Fifre, A., Carpentier, M., ... & Denys, A. (2018). Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2) displays an unexpected subcellular localization in the plasma membrane. Biochimica et Biophysica Acta (BBA)-General Subjects, 1862(7), 1644-1655.

Danková, Z., Braný, D., Dvorská, D., Ňachajová, M., Fiolka, R., Grendár, M., ... & Žúbor, P. (2018). Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions. International journal of molecular medicine, 42(6), 3318-3328.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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