Rabbit Anti-HSD17B11 Recombinant Antibody (EG1561) (CBMAB-EN1863-LY)

Name: Rabbit Anti-HSD17B11 Recombinant Antibody (EG1561)
SKU: CBMAB-EN1863-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1561

Application

WB: 1:500~1:1000 ELISA: 1:5000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human HSD17B11.

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Hydroxysteroid 17-Beta Dehydrogenase 11

Introduction

Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]

Entrez Gene ID

51170

UniProt ID

Q8NBQ5

Alternative Names

Hydroxysteroid 17-Beta Dehydrogenase 11; Retinal Short-Chain Dehydrogenase/Reductase 2; Short Chain Dehydrogenase/Reductase Family 16C Member 2; Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-03; Dehydrogenase/Reductase SDR Family Member 8; CTCL-Associated Antigen HD-CL-03; EC 1.1.1.62; 17BHSD11; RETSDR2; SDR16C2; DHRS8; PAN1B; Short Chain Dehydrogenase/Reductase Family 16C, Member 2; Dehydrogenase/Reductase (SDR Family) Member 8;

Function

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

Biological Process

Androgen catabolic process Source: HGNC-UCL
Estrogen biosynthetic process Source: Reactome

Cellular Location

Endoplasmic reticulum; Lipid droplet. Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation.

Zhang, W., Wang, B., Wang, Q., Zhang, Z., Shen, Z., Ye, Y., ... & Wang, S. (2020). Lnc-HSD17B11-1: 1 functions as a competing endogenous RNA to promote colorectal cancer progression by sponging miR-338-3p to upregulate MACC1. Frontiers in Genetics, 11, 628.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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