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Rabbit Anti-HSD17B11 Recombinant Antibody (EG1561) (CBMAB-EN1863-LY)

The product is antibody recognizes HSD17B11. The antibody EG1561 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:5000.
See all HSD17B11 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1561
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human HSD17B11.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Hydroxysteroid 17-Beta Dehydrogenase 11
Introduction
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
Entrez Gene ID
51170
UniProt ID
Q8NBQ5
Alternative Names
Hydroxysteroid 17-Beta Dehydrogenase 11; Retinal Short-Chain Dehydrogenase/Reductase 2; Short Chain Dehydrogenase/Reductase Family 16C Member 2; Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-03; Dehydrogenase/Reductase SDR Family Member 8; CTCL-Associated Antigen HD-CL-03; EC 1.1.1.62; 17BHSD11; RETSDR2; SDR16C2; DHRS8; PAN1B; Short Chain Dehydrogenase/Reductase Family 16C, Member 2; Dehydrogenase/Reductase (SDR Family) Member 8;
Function
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
Biological Process
Androgen catabolic process Source: HGNC-UCL
Estrogen biosynthetic process Source: Reactome
Cellular Location
Endoplasmic reticulum; Lipid droplet. Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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