Mouse Anti-HSD17B14 (AA 2-270) Recombinant Antibody (CBFYH-2006) (CBMAB-H3017-FY)

This product is mouse antibody that recognizes HSD17B14. The antibody CBFYH-2006 can be used for immunoassay techniques such as: IHC.
See all HSD17B14 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-2006

Antibody Isotype

IgG2b

Application

IHC

Basic Information

Immunogen

Recombinant corresponding to AA 2-270 from human HSD17B14 expressed in E. coli

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 2-270

Target

Full Name

Hydroxysteroid 17-Beta Dehydrogenase 14

Introduction

17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics.

Entrez Gene ID

51171

UniProt ID

Q9BPX1

Alternative Names

Hydroxysteroid 17-Beta Dehydrogenase 14; Short Chain Dehydrogenase/Reductase Family 47C Member 1; Retinal Short-Chain Dehydrogenase/Reductase RetSDR3; Dehydrogenase/Reductase (SDR Family) Member 10; Retinal Short-Chain Dehydrogenase/Reductase 3; 17-Beta-Hydroxysteroid Dehydrogenase DHRS10; 17-Beta-HSD 14; SDR47C1; DHRS10

Function

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).

Biological Process

Steroid catabolic process Source: HGNC-UCL

Cellular Location

Cytoplasm

References

Gao, S., Zhao, J., Xu, Q., Guo, Y., Liu, M., Zhang, C., ... & Zhou, B. (2022). MiR-31 targets HSD17B14 and FSHR, and miR-20b targets HSD17B14 to affect apoptosis and steroid hormone metabolism of porcine ovarian granulosa cells. Theriogenology, 180, 94-102.

Mychaleckyj, J. C., Valo, E., Ichimura, T., Ahluwalia, T. S., Dina, C., Miller, R. G., ... & Krolewski, A. S. (2021). Association of coding variants in hydroxysteroid 17-beta dehydrogenase 14 (HSD17B14) with reduced progression to end stage kidney disease in type 1 diabetes. Journal of the American Society of Nephrology, 32(10), 2634-2651.

Gao, S., Tao, R., Tong, X., Xu, Q., Zhao, J., Guo, Y., ... & Zhou, B. (2020). Identification of functional single nucleotide polymorphisms in porcine HSD17B14 gene associated with estrus behavior difference between large white and Mi gilts. Biomolecules, 10(11), 1545.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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