Human Recombinant HSD17B14 protein, His Tag (V2LY-0526-LY4585)

Name: Human Recombinant HSD17B14 protein, His Tag
SKU: V2LY-0526-LY4585
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant HSD17B14 protein, His Tag consist of Amino Acid: 1-270 and predicts a molecular mass of 29.8 kDa.

Molecule Mass

29.8 kDa

Sequence

Amino Acid: 1-270

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile This product is Lyophilized from sterile PBS, 5% Trehalose, 5% Mannitol, pH 7.4.
Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Hydroxysteroid 17-Beta Dehydrogenase 14

Function

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).

Biological Process

Steroid catabolic process Source: HGNC-UCL

Cellular Location

Cytoplasm

Gao, S., Zhao, J., Xu, Q., Guo, Y., Liu, M., Zhang, C., ... & Zhou, B. (2022). MiR-31 targets HSD17B14 and FSHR, and miR-20b targets HSD17B14 to affect apoptosis and steroid hormone metabolism of porcine ovarian granulosa cells. Theriogenology, 180, 94-102.

Mychaleckyj, J. C., Valo, E., Ichimura, T., Ahluwalia, T. S., Dina, C., Miller, R. G., ... & Krolewski, A. S. (2021). Association of coding variants in hydroxysteroid 17-beta dehydrogenase 14 (HSD17B14) with reduced progression to end stage kidney disease in type 1 diabetes. Journal of the American Society of Nephrology, 32(10), 2634-2651.

Gao, S., Tao, R., Tong, X., Xu, Q., Zhao, J., Guo, Y., ... & Zhou, B. (2020). Identification of functional single nucleotide polymorphisms in porcine HSD17B14 gene associated with estrus behavior difference between large white and Mi gilts. Biomolecules, 10(11), 1545.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-HSD17B14 (AA 2-270) Recombinant Antibody (CBFYH-2006) (CAT#: CBMAB-H3017-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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