Mouse Anti-HSF2 (AA 74-324) Recombinant Antibody (CBFYH-2044) (CBMAB-H3062-FY)

Name: Mouse Anti-HSF2 (AA 74-324) Recombinant Antibody (CBFYH-2044)
SKU: CBMAB-H3062-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-2044

Application

WB, IHC

Immunogen

Human recombinant protein fragment corresponding to amino acids 74-324 of human HSF2 produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 74-324

More Infomation

Target

Full Name

heat shock transcription factor 2

Introduction

The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

3298

UniProt ID

Q03933

Alternative Names

Heat Shock Transcription Factor 2; HSTF 2; HSTF2; HSF 2

Function

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Biological Process

Positive regulation of transcription by RNA polymerase II Source: MGI
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: Ensembl

Cellular Location

Nucleus; Cytoplasm. Cytoplasmic during normal growth and moves to the nucleus upon activation.

Tokunaga, Y., Otsuyama, K. I., Kakuta, S., & Hayashida, N. (2022). Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases. International Journal of Molecular Sciences, 23(22), 13763.

Vijayavittal, A. K., Kumar, P., Sugunan, S., Joseph, C., Devaki, B., Paithankar, K., & Subbarao, S. A. (2022). Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis. Biochemical and Biophysical Research Communications, 600, 44-50.

Liang, H., Zhang, F., Wang, W., Zhao, W., Zhou, J., Feng, Y., ... & Miao, Y. (2022). Heat shock transcription factor 2 promotes mitophagy of intestinal epithelial cells through PARL/PINK1/Parkin pathway in ulcerative colitis. Frontiers in Pharmacology, 13, 893426.

Zhang, F., Zhao, W., Zhou, J., Wang, W., Luo, J., Feng, Y., ... & Miao, Y. (2021). Heat shock transcription factor 2 reduces the secretion of IL-1β by inhibiting NLRP3 inflammasome activation in ulcerative colitis. Gene, 768, 145299.

Drissi, I., Deschamps, C., Alary, R., Robert, A., Dubreuil, V., Le Mouël, A., ... & Pierrefiche, O. (2021). Role of heat shock transcription factor 2 in the NMDA‐dependent neuroplasticity induced by chronic ethanol intake in mouse hippocampus. Addiction Biology, 26(2), e12939.

Wang, W., Zhang, F., Li, X., Luo, J., Sun, Y., Wu, J., ... & Miao, Y. (2020). Heat shock transcription factor 2 inhibits intestinal epithelial cell apoptosis through the mitochondrial pathway in ulcerative colitis. Biochemical and Biophysical Research Communications, 527(1), 173-179.

Zhang, F., Wang, W., Niu, J., Yang, G., Luo, J., Lan, D., ... & Miao, Y. (2020). Heat-shock transcription factor 2 promotes sodium butyrate-induced autophagy by inhibiting mTOR in ulcerative colitis. Experimental cell research, 388(1), 111820.

Joutsen, J., Da Silva, A. J., Luoto, J. C., Budzynski, M. A., Nylund, A. S., de Thonel, A., ... & Sistonen, L. (2020). Heat shock factor 2 protects against proteotoxicity by maintaining cell-cell adhesion. Cell Reports, 30(2), 583-597.

Wen, Y., Niu, J., Zhang, F., Wu, J., Li, M., Sun, Y., ... & Miao, Y. (2020). Heat shock transcription factor 2 predicts mucosal healing and promotes mucosal repair of ulcerative colitis. Scandinavian Journal of Gastroenterology, 55(6), 677-686.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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