Mouse Anti-HSPA13 (AA 375-470) Recombinant Antibody (CBFYH-2170) (CBMAB-H3191-FY)

Name: Mouse Anti-HSPA13 (AA 375-470) Recombinant Antibody (CBFYH-2170)
SKU: CBMAB-H3191-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-2170

Application

ELISA, IF, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: EDLFQKILVP IQQVLKEGHL EKTEIDEVVL VGGSTRIPRI RQVIQEFFGK DPNTSVDPDL AVVTGVAIQA GIDGGSWPLQ VSALEIPNKH LQKTNF

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 375-470

More Infomation

Target

Full Name

Heat Shock Protein Family A (Hsp70) Member 13

Introduction

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein.

Entrez Gene ID

6782

UniProt ID

P48723

Alternative Names

Heat Shock Protein Family A (Hsp70) Member 13; Stress-70 Protein Chaperone Microsome-Associated 60 KDa Protein; Stress 70 Protein Chaperone, Microsome-Associated, 60kDa; Stress 70 Protein Chaperone, Microsome-Associated, 60kD; Heat Shock Protein 70kDa Family, Member 13; STCH

Function

Has peptide-independent ATPase activity.

Biological Process

Cellular response to unfolded protein Source: GO_Central
Chaperone cofactor-dependent protein refolding Source: GO_Central
Protein refolding Source: GO_Central

Cellular Location

Microsome; Endoplasmic reticulum

Espinoza, M. F., Nguyen, K. K., Sycks, M. M., Lyu, Z., Quanrud, G. M., Montoya, M. R., & Genereux, J. C. (2022). Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation. Journal of Biological Chemistry, 298(12).

Zhai, B., Liu, X., Xu, Y., Zhu, G., Zhou, S., He, Y., ... & Wang, R. (2022). Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation. Molecular Immunology, 141, 79-86.

Espinoza, M. F., Nguyen, K. K., Sycks, M. M., Lyu, Z., Montoya, M. R., & Genereux, J. C. (2022). Hspa13 Regulates Endoplasmic Reticulum and Cytosolic Proteostasis Through Modulation of Protein Translocation. bioRxiv, 2022-06.

Gao, C., Deng, J., Zhang, H., Li, X., Gu, S., Zheng, M., ... & Feng, X. H. (2021). HSPA13 facilitates NF-κB–mediated transcription and attenuates cell death responses in TNFα signaling. Science Advances, 7(41), eabh1756.

He, Y., Xu, R., Zhai, B., Fang, Y., Hou, C., Xing, C., ... & Wang, R. (2020). Hspa13 promotes plasma cell production and antibody secretion. Frontiers in Immunology, 11, 913.

Yun, C. H., Kim, Y. C., & Jeong, B. H. (2018). The First Report on Single Nucleotide Polymorphisms of the HSPA13 Gene in Koreans. Russian Journal of Genetics, 54, 353-357.

Genereux, J. (2018). The ER Hsp70 Hspa13 Redirects an Amyloidogenic Protein to Aggregation. The FASEB Journal, 32, 794-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

HSPA13 Matched Antibody Pair (575) (CAT#: APMAB-575LY)

Related Products

HSPA13 Matched Antibody Pair (575) (CAT#: APMAB-575LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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