Rabbit Anti-HSPB11 Recombinant Antibody (CBWJC-3768) (CBMAB-C5034WJ)

Name: Rabbit Anti-HSPB11 Recombinant Antibody (CBWJC-3768)
SKU: CBMAB-C5034WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBWJC-3768

Application

Specificity

Mouse, Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Heat Shock Protein Family B (Small) Member 11

Introduction

HSPB11 (Heat Shock Protein Family B (Small) Member 11) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport.

Entrez Gene ID

Human	51668
Mouse	72938

UniProt ID

Human	Q9Y547
Mouse	Q9D6H2

Alternative Names

Heat Shock Protein Family B (Small) Member 11; Heat Shock Protein Family B (Small), Member 11; Heat Shock Protein Beta-11; Placental Protein 25; C1orf41; IFT25; PP25;

Function

Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Heart development Source: Ensembl
Intraciliary transport Source: InterPro
Kidney development Source: UniProtKB
Left/right axis specification Source: Ensembl
Lung development Source: Ensembl
Protein transport Source: UniProtKB-KW
Skeletal system development Source: Ensembl
Smoothened signaling pathway Source: Ensembl
Spermatogenesis Source: UniProtKB

Cellular Location

Cilium

Liu, H., Yang, M., & Dong, Z. (2022). HSPB11 is a Prognostic Biomarker Associated with Immune Infiltrates in Hepatocellular Carcinoma. International Journal of General Medicine, 4017-4027.

Shields, J. N., Hales, E. C., Ranspach, L. E., Luo, X., Orr, S., Runft, D., ... & Thummel, R. (2019). Exposure of larval zebrafish to the insecticide propoxur induced developmental delays that correlate with behavioral abnormalities and altered expression of hspb9 and hspb11. Toxics, 7(4), 50.

Zhang, R., Wang, X., Zhang, X., Zhang, J., Zhang, X., Shi, X., ... & Liu, C. (2018). Down-regulation of hspb9 and hspb11 contributes to wavy notochord in zebrafish embryos following exposure to polychlorinated diphenylsulfides. Environmental science & technology, 52(21), 12829-12840.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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