HSPB11

HSPB11 (Heat Shock Protein Family B (Small) Member 11) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport.

Full Name

Heat Shock Protein Family B (Small) Member 11

Function

Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Heart development Source: Ensembl
Intraciliary transport Source: InterPro
Kidney development Source: UniProtKB
Left/right axis specification Source: Ensembl
Lung development Source: Ensembl
Protein transport Source: UniProtKB-KW
Skeletal system development Source: Ensembl
Smoothened signaling pathway Source: Ensembl
Spermatogenesis Source: UniProtKB

Cellular Location

Cilium