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Mouse Anti-HSPB7 Recombinant Antibody (3E11) (CBMAB-A4134-LY)

The product is antibody recognizes HSPB7. The antibody 3E11 immunoassay techniques such as: WB, ELISA.
See all HSPB7 antibodies
Published Data
Fig.1 Fusion of HSPB7 with ECFP and expression in HeLa S3 cells.
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Fig.2 Immunofluorescent staining of HSPBs (red) in HEK293 cells.
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Fig.3 Colocalization of the HSPBs with PARK2 C289G aggregates.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3E11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HSPB7 (AAH06319, 1 a.a. ~ 170 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
heat shock 27kDa protein family, member 7 (cardiovascular)
Entrez Gene ID
27129
UniProt ID
Q9UBY9
Alternative Names
DKFZp779D0968; FLJ32733; cvHSP
Biological Process
Heart development Source: InterPro
Regulation of heart contraction Source: ProtInc
Response to unfolded protein Source: ProtInc
Cellular Location
Cytoplasm; Nucleus; Cajal body. Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

Zhang, S., van de Peppel, J., Koedam, M., van Leeuwen, J. P., & van der Eerden, B. C. (2023). HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis. Stem Cell Research & Therapy, 14(1), 1-15.

Muranova, L. K., Shatov, V. M., Slushchev, A. V., & Gusev, N. B. (2022). Is the small heat shock protein HSPB7 (cvHsp) a genuine actin-binding protein?. Biochimie, 202, 103-109.

Muranova, L. K., Shatov, V. M., Bukach, O. V., & Gusev, N. B. (2021). Cardio-vascular heat shock protein (cvHsp, HspB7), an unusual representative of small heat shock protein family. Biochemistry (Moscow), 86, S1-S11.

Muranova, L. K., Shatov, V. M., Slushchev, A. V., & Gusev, N. B. (2021). Quaternary structure and hetero-oligomerization of recombinant human small heat shock protein HspB7 (cvHsp). International Journal of Molecular Sciences, 22(15), 7777.

Kim, J., Aydemir, T. B., Jimenez-Rondan, F. R., Ruggiero, C. H., Kim, M. H., & Cousins, R. J. (2020). Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7. Scientific Reports, 10(1), 4050.

Jin, C., Shuai, T., & Tang, Z. (2020). HSPB7 regulates osteogenic differentiation of human adipose derived stem cells via ERK signaling pathway. Stem Cell Research & Therapy, 11(1), 1-13.

Wu, D., Vonk, J. J., Salles, F., Vonk, D., Haslbeck, M., Melki, R., ... & Kampinga, H. H. (2019). The N terminus of the small heat shock protein HSPB7 drives its polyQ aggregation–suppressing activity. Journal of Biological Chemistry, 294(25), 9985-9994.

Surya, S. L., Long, M. J., Urul, D. A., Zhao, Y., Mercer, E. J., EIsaid, I. M., ... & Aye, Y. (2018). Cardiovascular small heat shock protein HSPB7 is a kinetically privileged reactive electrophilic species (RES) sensor. ACS chemical biology, 13(7), 1824-1831.

Mercer, E. J., Lin, Y. F., Cohen-Gould, L., & Evans, T. (2018). Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis. Developmental biology, 435(1), 41-55.

Naderi, A. (2018). SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies. Molecular Oncology, 12(5), 724-755.

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For research use only. Not intended for any clinical use.

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