Mouse Anti-HTR1D Recombinant Antibody (CBXS-2289) (CBMAB-S5051-CQ)

Name: Mouse Anti-HTR1D Recombinant Antibody (CBXS-2289)
SKU: CBMAB-S5051-CQ
Rating: 5 (1 reviews)

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Datasheet

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-2289

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

5-Hydroxytryptamine Receptor 1D

Introduction

HTR1D (5-Hydroxytryptamine Receptor 1D) is a Protein Coding gene. Diseases associated with HTR1D include Migraine With Or Without Aura 1 and Major Depressive Disorder. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1B.

Entrez Gene ID

Human	3352
Mouse	15552
Rat	25323

UniProt ID

Human	P28221
Mouse	Q61224
Rat	P28565

Alternative Names

5-Hydroxytryptamine Receptor 1D; 5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled; Serotonin 1D Alpha Receptor; Serotonin Receptor 1D; 5-HT-1D-Alpha; 5-HT-1D; 5-HT1D;

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Intestine smooth muscle contraction Source: UniProtKB
Regulation of behavior Source: InterPro
Regulation of locomotion Source: InterPro
Vasoconstriction Source: InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 1-38
Helical: 39-64
Cytoplasmic: 65-75
Helical: 76-98
Extracellular: 99-112
Helical: 113-134
Cytoplasmic: 135-154
Helical: 155-176
Extracellular: 177-194
Helical: 195-217
Cytoplasmic: 218-302
Helical: 303-326
Extracellular: 327-335
Helical: 336-360
Cytoplasmic: 361-377

Wu, W., Li, Q., Zhu, Z., Li, C., Lu, P., Zhou, X., ... & Gong, J. (2022). HTR1D functions as a key target of HOXA10-AS/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway. International Journal of Biological Sciences, 18(9), 3777.

Zeng, C., & Chen, Y. (2019). HTR1D, TIMP1, SERPINE1, MMP3 and CNR2 affect the survival of patients with colon adenocarcinoma. Oncology letters, 18(3), 2448-2454.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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