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Mouse Anti-HTR1D Recombinant Antibody (CBXS-2289) (CBMAB-S5051-CQ)

This product is a mouse antibody that recognizes HTR1D. The antibody CBXS-2289 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all HTR1D antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2289
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5-Hydroxytryptamine Receptor 1D
Introduction
HTR1D (5-Hydroxytryptamine Receptor 1D) is a Protein Coding gene. Diseases associated with HTR1D include Migraine With Or Without Aura 1 and Major Depressive Disorder. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1B.
Entrez Gene ID
Human3352
Mouse15552
Rat25323
UniProt ID
HumanP28221
MouseQ61224
RatP28565
Alternative Names
5-Hydroxytryptamine Receptor 1D; 5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled; Serotonin 1D Alpha Receptor; Serotonin Receptor 1D; 5-HT-1D-Alpha; 5-HT-1D; 5-HT1D;
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Intestine smooth muscle contraction Source: UniProtKB
Regulation of behavior Source: InterPro
Regulation of locomotion Source: InterPro
Vasoconstriction Source: InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 1-38
Helical: 39-64
Cytoplasmic: 65-75
Helical: 76-98
Extracellular: 99-112
Helical: 113-134
Cytoplasmic: 135-154
Helical: 155-176
Extracellular: 177-194
Helical: 195-217
Cytoplasmic: 218-302
Helical: 303-326
Extracellular: 327-335
Helical: 336-360
Cytoplasmic: 361-377
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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