HTR1D

HTR1D (5-Hydroxytryptamine Receptor 1D) is a Protein Coding gene. Diseases associated with HTR1D include Migraine With Or Without Aura 1 and Major Depressive Disorder. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1B.

Full Name

5-Hydroxytryptamine Receptor 1D

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Intestine smooth muscle contraction Source: UniProtKB
Regulation of behavior Source: InterPro
Regulation of locomotion Source: InterPro
Vasoconstriction Source: InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 1-38
Helical: 39-64
Cytoplasmic: 65-75
Helical: 76-98
Extracellular: 99-112
Helical: 113-134
Cytoplasmic: 135-154
Helical: 155-176
Extracellular: 177-194
Helical: 195-217
Cytoplasmic: 218-302
Helical: 303-326
Extracellular: 327-335
Helical: 336-360
Cytoplasmic: 361-377