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Mouse Anti-HTR3D Recombinant Antibody (CBFYH-2502) (CBMAB-H3516-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2502
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5-Hydroxytryptamine Receptor 3D
Introduction
The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
200909
UniProt ID
Q70Z44
Alternative Names
5-Hydroxytryptamine Receptor 3D; 5-Hydroxytryptamine (Serotonin) Receptor 3 Family Member D; 5-Hydroxytryptamine (Serotonin) Receptor 3D, Ionotropic; Serotonin Receptor 3D; 5-Hydroxytryptamine Receptor 3 Subunit D; Serotonin 5-HT-3D Receptor; 5-HT3-D; 5-HT3D; 5HT3D
Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Biological Process
Chemical synaptic transmission Source: GO_Central
Inorganic cation transmembrane transport Source: ComplexPortal
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Serotonin receptor signaling pathway Source: ComplexPortal
Signal transduction Source: GO_Central
Cellular Location
Cell membrane. Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Topology
Extracellular: 25-232
Helical: 233-253
Cytoplasmic: 254-264
Helical: 265-285
Extracellular: 286-306
Helical: 307-327
Cytoplasmic: 328-431
Helical: 432-452
Extracellular: 453-454
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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