Mouse Anti-HTR3D Recombinant Antibody (CBFYH-2502) (CBMAB-H3516-FY)

Name: Mouse Anti-HTR3D Recombinant Antibody (CBFYH-2502)
SKU: CBMAB-H3516-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-2502

Application

WB, IP, IF, ELISA

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

5-Hydroxytryptamine Receptor 3D

Introduction

The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

200909

UniProt ID

Q70Z44

Alternative Names

5-Hydroxytryptamine Receptor 3D; 5-Hydroxytryptamine (Serotonin) Receptor 3 Family Member D; 5-Hydroxytryptamine (Serotonin) Receptor 3D, Ionotropic; Serotonin Receptor 3D; 5-Hydroxytryptamine Receptor 3 Subunit D; Serotonin 5-HT-3D Receptor; 5-HT3-D; 5-HT3D; 5HT3D

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Biological Process

Chemical synaptic transmission Source: GO_Central
Inorganic cation transmembrane transport Source: ComplexPortal
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Serotonin receptor signaling pathway Source: ComplexPortal
Signal transduction Source: GO_Central

Cellular Location

Cell membrane. Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Topology

Extracellular: 25-232
Helical: 233-253
Cytoplasmic: 254-264
Helical: 265-285
Extracellular: 286-306
Helical: 307-327
Cytoplasmic: 328-431
Helical: 432-452
Extracellular: 453-454

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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