HTR3D

The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Full Name

5-Hydroxytryptamine Receptor 3D

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Biological Process

Chemical synaptic transmission Source: GO_Central
Inorganic cation transmembrane transport Source: ComplexPortal
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Serotonin receptor signaling pathway Source: ComplexPortal
Signal transduction Source: GO_Central

Cellular Location

Cell membrane. Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Topology

Extracellular: 25-232
Helical: 233-253
Cytoplasmic: 254-264
Helical: 265-285
Extracellular: 286-306
Helical: 307-327
Cytoplasmic: 328-431
Helical: 432-452
Extracellular: 453-454