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Mouse Anti-HUNK Recombinant Antibody (1E4) (CBMAB-A4172-LY)

The product is antibody recognizes HUNK. The antibody 1E4 immunoassay techniques such as: WB, ELISA.
See all HUNK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HUNK (NP_055401, 615 a.a. ~ 714 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
HORMONALLY UP-REGULATED NEU-ASSOCIATED KINASE
Entrez Gene ID
30811
UniProt ID
P57058
Biological Process
Intracellular signal transduction Source: GO_Central
Multicellular organism development Source: ProtInc
Protein phosphorylation Source: GO_Central
Signal transduction Source: ProtInc

Dilday, T., Abt, M., Sintim, H., Sandusky, G., & Yeh, E. S. (2023). Identification and Testing of a Novel HUNK Inhibitor.

Solis, N. R., Yeh, E. S., Kaplan, M. H., & Cannon, A. M. (2023). HUNK regulation of IL-4 promotes polarization of tumor-associated macrophages in TNBC tumor microenvironment.

Ramos Solis, N., & Yeh, E. S. (2022). HUNK regulation of interleukin 4 in triple negative breast cancer. The FASEB Journal, 36.

Ramos-Solis, N., Dilday, T., Kritikos, A. E., & Yeh, E. S. (2022). HUNK Gene Alterations in Breast Cancer. Biomedicines, 10(12), 3072.

Dilday, T., Ramos, N., & Yeh, E. (2020). HUNK signaling in metastatic breast cancer. Oncoscience, 7(5-6), 30.

Williams, C. B., Phelps-Polirer, K., Dingle, I. P., Williams, C. J., Rhett, M. J., Eblen, S. T., ... & Yeh, E. S. (2020). HUNK phosphorylates EGFR to regulate breast cancer metastasis. Oncogene, 39(5), 1112-1124.

Zambrano, J. N., Eblen, S. T., Abt, M., Rhett, J. M., Muise-Helmericks, R., & Yeh, E. S. (2019). HUNK phosphorylates rubicon to support autophagy. International Journal of Molecular Sciences, 20(22), 5813.

Lakshmanan, A., Rabaglia, M., Das, R., Schueler, K., Stapleton, D., Simonett, S., ... & Attie, A. (2018). Hunk, a Serine/Threonine Protein Kinase, Regulates Insulin Secretion from Pancreatic Islets. The FASEB Journal, 32, 670-15.

Zambrano, J. N., Williams, C. J., Williams, C. B., Hedgepeth, L., Burger, P., Dilday, T., ... & Yeh, E. S. (2018). Staurosporine, an inhibitor of hormonally up-regulated neu-associated kinase. Oncotarget, 9(89), 35962.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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