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Mouse Anti-ICOS Recombinant Antibody (3G4) (CBMAB-A4189-LY)

The product is antibody recognizes ICOS. The antibody 3G4 immunoassay techniques such as: WB, ELISA.
See all ICOS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ICOS (NP_036224.1, 21 a.a. ~ 140 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Inducible T Cell Costimulator
Introduction
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq]
Entrez Gene ID
29851
UniProt ID
Q9Y6W8
Alternative Names
AILIM; CD278; MGC39850
Function
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Biological Process
Cell-cell adhesion Source: GO_Central
Immune response Source: UniProtKB
T cell costimulation Source: GO_Central
T cell tolerance induction Source: GO_Central
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Involvement in disease
Immunodeficiency, common variable, 1 (CVID1):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Extracellular: 21-140
Helical: 141-161
Cytoplasmic: 162-199
PTM
N-glycosylated.

Chavez, J. C., Foss, F. M., William, B. M., Brammer, J. E., Smith, S. M., Prica, A., ... & Siu, L. L. (2023). Targeting the Inducible T-cell Costimulator (ICOS) in Patients with Relapsed/Refractory T-follicular Helper Phenotype Peripheral T-cell and Angioimmunoblastic T-cell Lymphoma. Clinical Cancer Research, 29(10), 1869-1878.

Boggio, E., Gigliotti, C. L., Moia, R., Scotta, A., Crespi, I., Boggione, P., ... & Dianzani, U. (2022). Inducible T‐cell co‐stimulator (ICOS) and ICOS ligand are novel players in the multiple‐myeloma microenvironment. British Journal of Haematology, 196(6), 1369-1380.

Di Raimondo, C., Rubio‐Gonzalez, B., Palmer, J., Weisenburger, D. D., Zain, J., Wu, X., ... & Querfeld, C. (2022). Expression of immune checkpoint molecules programmed death protein 1, programmed death‐ligand 1 and inducible T‐cell co‐stimulator in mycosis fungoides and Sézary syndrome: association with disease stage and clinical outcome. British Journal of Dermatology, 187(2), 234-243.

Ramavath, N. N., Gadipudi, L. L., Provera, A., Gigliotti, L. C., Boggio, E., Bozzola, C., ... & Sutti, S. (2021). Inducible T-cell costimulator mediates lymphocyte/macrophage interactions during liver repair. Frontiers in Immunology, 12, 786680.

Raineri, D., Cappellano, G., Vilardo, B., Maione, F., Clemente, N., Canciani, E., ... & Chiocchetti, A. (2021). Inducible T-cell costimulator ligand plays a dual role in melanoma metastasis upon binding to osteopontin or inducible T-cell costimulator. Biomedicines, 10(1), 51.

Solinas, C., Gu-Trantien, C., & Willard-Gallo, K. (2020). The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy. ESMO open, 5(1), e000544.

Rischin, D., Groenland, S. L., Lim, A. M. L., Martin-Liberal, J., Moreno, V., Perez, J. T., ... & Angevin, E. (2019). Inducible T cell costimulatory (ICOS) receptor agonist, GSK3359609 (GSK609) alone and in combination with pembrolizumab (pembro): Preliminary results from INDUCE-1 expansion cohorts (EC) in head and neck squamous cell carcinoma (HNSCC). Annals of Oncology, 30, v454-v455.

Panneton, V., Chang, J., Witalis, M., Li, J., & Suh, W. K. (2019). Inducible T‐cell co‐stimulator: signaling mechanisms in T follicular helper cells and beyond. Immunological Reviews, 291(1), 91-103.

Zhang, M., Wu, Y., Bastian, D., Iamsawat, S., Chang, J., Daenthanasanmak, A., ... & Yu, X. Z. (2018). Inducible T-cell co-stimulator impacts chronic graft-versus-host disease by regulating both pathogenic and regulatory T cells. Frontiers in Immunology, 9, 1461.

Amatore, F., Gorvel, L., & Olive, D. (2018). Inducible Co-Stimulator (ICOS) as a potential therapeutic target for anti-cancer therapy. Expert opinion on therapeutic targets, 22(4), 343-351.

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For research use only. Not intended for any clinical use.

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