ICOS
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Full Name
Inducible T Cell Costimulator
Alternative Names
Inducible T Cell Costimulator
Function
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Biological Process
Cell-cell adhesion Source: GO_Central
Immune response Source: UniProtKB
T cell costimulation Source: GO_Central
T cell tolerance induction Source: GO_Central
Immune response Source: UniProtKB
T cell costimulation Source: GO_Central
T cell tolerance induction Source: GO_Central
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 2: Secreted
Involvement in disease
Immunodeficiency, common variable, 1 (CVID1):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Extracellular: 21-140
Helical: 141-161
Cytoplasmic: 162-199
Helical: 141-161
Cytoplasmic: 162-199
PTM
N-glycosylated.
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Anti-ICOS antibodies
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CompareTarget: ICOS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G4
Application*: WB, E
Target: ICOS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP98
Application*: IH, P
Target: ICOS
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AG89
Application*: B, WB
Target: ICOS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1K2T
Application*: IH, P
Target: Icos
Sensitivity: 0.024 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: ICOS
Sensitivity: 0.0056 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-140
Tag: hFc Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-140
Tag: hFc & AVI Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-142
Tag: hFc Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-144
Tag: rFc Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-135
Tag: His Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-135
Tag: His Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-142
Tag: hFc Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-142
Tag: hFc & AVI Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: rFc Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-134
Tag: His Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: hFc Tag
Target: ICOS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: hFc Tag
Target: ICOS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ISA-3
Application*: F, FN, C, IP
Target: ICOS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2184
Application*: F
Target: ICOS
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse, Rat, Monkey
Clone: CBWJC-2183
Application*: F, FN, IH, IP
Target: ICOS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2182
Application*: F, E
Target: ICOS
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-C0578
Application*: F, FN, N, B
Target: ICOS
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-0734
Application*: F
Target: ICOS
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYC-0343
Application*: F
Target: ICOS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1839
Application*: E, F
Target: ICOS
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1519
Application*: F, MC
Target: ICOS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1343
Application*: E, N, WB
Target: ICOS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0838
Application*: E, F, FN
Target: ICOS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0821
Application*: F, IH
Target: ICOS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0795
Application*: E, F, N, WB
Target: ICOS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0758
Application*: E, F
Target: ICOS
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 670306
Application*: F, MC
Target: ICOS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0689
Application*: F, BL, MC
Target: ICOS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0688
Application*: F, MC
Target: ICOS
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 669214
Application*: F, MC
Target: ICOS
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: C398.4A
Application*: F, C, IP
Target: ICOS
Host: Hamster
Antibody Isotype: IgM
Specificity: Mouse
Clone: 27A12
Application*: F, IH, FN, IP, C
Target: ICOS
Host: Hamster
Specificity: Mouse
Clone: 15F9
Application*: IF, F
Target: ICOS
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 7E.17G9
Application*: B, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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