Mouse Recombinant ICOS protein, His Tag (V2LY-0526-LY8420)

Name: Mouse Recombinant ICOS protein, His Tag
SKU: V2LY-0526-LY8420
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant ICOS protein, His Tag consist of Amino Acid: 1-135 and predicts a molecular mass of 13.9 kDa.

Molecule Mass

13.9 kDa

Sequence

Amino Acid: 1-135

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Inducible T Cell Costimulator

Alternative Names

Inducible T Cell Costimulator

Function

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

Biological Process

Cell-cell adhesion Source: GO_Central
Immune response Source: UniProtKB
T cell costimulation Source: GO_Central
T cell tolerance induction Source: GO_Central

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Secreted

Involvement in disease

Immunodeficiency, common variable, 1 (CVID1):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Topology

Extracellular: 21-140
Helical: 141-161
Cytoplasmic: 162-199

PTM

N-glycosylated.

Chavez, J. C., Foss, F. M., William, B. M., Brammer, J. E., Smith, S. M., Prica, A., ... & Siu, L. L. (2023). Targeting the Inducible T-cell Costimulator (ICOS) in Patients with Relapsed/Refractory T-follicular Helper Phenotype Peripheral T-cell and Angioimmunoblastic T-cell Lymphoma. Clinical Cancer Research, 29(10), 1869-1878.

Boggio, E., Gigliotti, C. L., Moia, R., Scotta, A., Crespi, I., Boggione, P., ... & Dianzani, U. (2022). Inducible T‐cell co‐stimulator (ICOS) and ICOS ligand are novel players in the multiple‐myeloma microenvironment. British Journal of Haematology, 196(6), 1369-1380.

Di Raimondo, C., Rubio‐Gonzalez, B., Palmer, J., Weisenburger, D. D., Zain, J., Wu, X., ... & Querfeld, C. (2022). Expression of immune checkpoint molecules programmed death protein 1, programmed death‐ligand 1 and inducible T‐cell co‐stimulator in mycosis fungoides and Sézary syndrome: association with disease stage and clinical outcome. British Journal of Dermatology, 187(2), 234-243.

Ramavath, N. N., Gadipudi, L. L., Provera, A., Gigliotti, L. C., Boggio, E., Bozzola, C., ... & Sutti, S. (2021). Inducible T-cell costimulator mediates lymphocyte/macrophage interactions during liver repair. Frontiers in Immunology, 12, 786680.

Raineri, D., Cappellano, G., Vilardo, B., Maione, F., Clemente, N., Canciani, E., ... & Chiocchetti, A. (2021). Inducible T-cell costimulator ligand plays a dual role in melanoma metastasis upon binding to osteopontin or inducible T-cell costimulator. Biomedicines, 10(1), 51.

Solinas, C., Gu-Trantien, C., & Willard-Gallo, K. (2020). The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy. ESMO open, 5(1), e000544.

Rischin, D., Groenland, S. L., Lim, A. M. L., Martin-Liberal, J., Moreno, V., Perez, J. T., ... & Angevin, E. (2019). Inducible T cell costimulatory (ICOS) receptor agonist, GSK3359609 (GSK609) alone and in combination with pembrolizumab (pembro): Preliminary results from INDUCE-1 expansion cohorts (EC) in head and neck squamous cell carcinoma (HNSCC). Annals of Oncology, 30, v454-v455.

Panneton, V., Chang, J., Witalis, M., Li, J., & Suh, W. K. (2019). Inducible T‐cell co‐stimulator: signaling mechanisms in T follicular helper cells and beyond. Immunological Reviews, 291(1), 91-103.

Zhang, M., Wu, Y., Bastian, D., Iamsawat, S., Chang, J., Daenthanasanmak, A., ... & Yu, X. Z. (2018). Inducible T-cell co-stimulator impacts chronic graft-versus-host disease by regulating both pathogenic and regulatory T cells. Frontiers in Immunology, 9, 1461.

Amatore, F., Gorvel, L., & Olive, D. (2018). Inducible Co-Stimulator (ICOS) as a potential therapeutic target for anti-cancer therapy. Expert opinion on therapeutic targets, 22(4), 343-351.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ICOS protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4634)

Human Recombinant ICOS protein, hFc Tag (CAT#: V2LY-0526-LY4635)

Human Recombinant ICOS protein, His Tag (CAT#: V2LY-0526-LY4636)

Human Recombinant ICOS protein, rFc Tag (CAT#: V2LY-0526-LY4637)

Mouse Recombinant ICOS protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY8418)

Mouse Recombinant ICOS protein, hFc Tag (CAT#: V2LY-0526-LY8419)

Mouse Recombinant ICOS protein, His Tag-1 (CAT#: V2LY-0526-LY8421)

Mouse Recombinant ICOS protein, rFc Tag (CAT#: V2LY-0526-LY8422)

Rat Recombinant ICOS protein, hFc Tag (CAT#: V2LY-0526-LY9427)

Rhesus Recombinant ICOS protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY9724)

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Rat Recombinant ICOS protein, hFc Tag (CAT#: V2LY-0526-LY9427)

Mouse Recombinant ICOS protein, His Tag-1 (CAT#: V2LY-0526-LY8421)

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Mouse Recombinant ICOS protein, hFc Tag (CAT#: V2LY-0526-LY8419)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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