Mouse Anti-IDO1 Recombinant Antibody (A383) (CBMAB-AP10824LY)

Name: Mouse Anti-IDO1 Recombinant Antibody (A383)
SKU: CBMAB-AP10824LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A383

Application

IF, IHC, IP, WB

Immunogen

Recombinant protein of human IDO1

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Indoleamine 2,3-Dioxygenase 1

Introduction

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Entrez Gene ID

3620

UniProt ID

P14902

Alternative Names

Indoleamine 2,3-Dioxygenase 1

Function

A10921

Biological Process

de novo' NAD biosynthetic process from tryptophan Source: GO_Central
Female pregnancy Source: ProtInc
Immune system process Source: UniProtKB-KW
Inflammatory response Source: Ensembl
Kynurenic acid biosynthetic process Source: Ensembl
Multicellular organismal response to stress Source: Ensembl
Negative regulation of interleukin-10 production Source: Ensembl
Negative regulation of T cell apoptotic process Source: Ensembl
Negative regulation of T cell proliferation Source: Ensembl
Positive regulation of chronic inflammatory response Source: Ensembl
Positive regulation of interleukin-12 production Source: Ensembl
Positive regulation of T cell apoptotic process Source: UniProtKB
Positive regulation of T cell tolerance induction Source: Ensembl
Positive regulation of type 2 immune response Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Swimming behavior Source: Ensembl
Tryptophan catabolic process Source: ProtInc
Tryptophan catabolic process to kynurenine Source: GO_Central

Cellular Location

Cytosol

Salminen, A. (2022). Role of indoleamine 2, 3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process. Ageing Research Reviews, 75, 101573.

Pallotta, M. T., Rossini, S., Suvieri, C., Coletti, A., Orabona, C., Macchiarulo, A., ... & Grohmann, U. (2022). Indoleamine 2, 3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme. The FEBS journal, 289(20), 6099-6118.

Fujiwara, Y., Kato, S., Nesline, M. K., Conroy, J. M., DePietro, P., Pabla, S., & Kurzrock, R. (2022). Indoleamine 2, 3-dioxygenase (IDO) inhibitors and cancer immunotherapy. Cancer Treatment Reviews, 102461.

Zhang, Y., Hu, Z., Zhang, J., Ren, C., & Wang, Y. (2022). Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy. European Journal of Medicinal Chemistry, 238, 114524.

Tang, K., Wu, Y. H., Song, Y., & Yu, B. (2021). Indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy. Journal of Hematology & Oncology, 14, 1-21.

Röhrig, U. F., Michielin, O., & Zoete, V. (2021). Structure and plasticity of indoleamine 2, 3-dioxygenase 1 (IDO1). Journal of Medicinal Chemistry, 64(24), 17690-17705.

Wang, X. X., Sun, S. Y., Dong, Q. Q., Wu, X. X., Tang, W., & Xing, Y. Q. (2019). Recent advances in the discovery of indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors. MedChemComm, 10(10), 1740-1754.

Röhrig, U. F., Reynaud, A., Majjigapu, S. R., Vogel, P., Pojer, F., & Zoete, V. (2019). Inhibition mechanisms of indoleamine 2, 3-dioxygenase 1 (IDO1). Journal of medicinal chemistry, 62(19), 8784-8795.

Nayak-Kapoor, A., Hao, Z., Sadek, R., Dobbins, R., Marshall, L., Vahanian, N. N., ... & Khleif, S. N. (2018). Phase Ia study of the indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors. Journal for immunotherapy of cancer, 6(1), 1-12.

Komiya, T., & Huang, C. H. (2018). Updates in the clinical development of epacadostat and other indoleamine 2, 3-dioxygenase 1 inhibitors (IDO1) for human cancers. Frontiers in oncology, 8, 423.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

IDO1 Matched Antibody Pair (585) (CAT#: APMAB-585LY)

IDO1 Matched Antibody Pair (586) (CAT#: APMAB-586LY)

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Isotype control

For research use only. Not intended for any clinical use.

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