IDO1
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
Full Name
Indoleamine 2,3-Dioxygenase 1
Function
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174).
Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885).
Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885).
Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885).
Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885).
Protects the fetus from maternal immune rejection (PubMed:25691885).
Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885).
Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885).
Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885).
Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885).
Protects the fetus from maternal immune rejection (PubMed:25691885).
Biological Process
de novo' NAD biosynthetic process from tryptophan Source: GO_Central
Female pregnancy Source: ProtInc
Immune system process Source: UniProtKB-KW
Inflammatory response Source: Ensembl
Kynurenic acid biosynthetic process Source: Ensembl
Multicellular organismal response to stress Source: Ensembl
Negative regulation of interleukin-10 production Source: Ensembl
Negative regulation of T cell apoptotic process Source: Ensembl
Negative regulation of T cell proliferation Source: Ensembl
Positive regulation of chronic inflammatory response Source: Ensembl
Positive regulation of interleukin-12 production Source: Ensembl
Positive regulation of T cell apoptotic process Source: UniProtKB
Positive regulation of T cell tolerance induction Source: Ensembl
Positive regulation of type 2 immune response Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Swimming behavior Source: Ensembl
Tryptophan catabolic process Source: ProtInc
Tryptophan catabolic process to kynurenine Source: GO_Central
Female pregnancy Source: ProtInc
Immune system process Source: UniProtKB-KW
Inflammatory response Source: Ensembl
Kynurenic acid biosynthetic process Source: Ensembl
Multicellular organismal response to stress Source: Ensembl
Negative regulation of interleukin-10 production Source: Ensembl
Negative regulation of T cell apoptotic process Source: Ensembl
Negative regulation of T cell proliferation Source: Ensembl
Positive regulation of chronic inflammatory response Source: Ensembl
Positive regulation of interleukin-12 production Source: Ensembl
Positive regulation of T cell apoptotic process Source: UniProtKB
Positive regulation of T cell tolerance induction Source: Ensembl
Positive regulation of type 2 immune response Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Swimming behavior Source: Ensembl
Tryptophan catabolic process Source: ProtInc
Tryptophan catabolic process to kynurenine Source: GO_Central
Cellular Location
Cytosol
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Anti-IDO1 antibodies
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CompareTarget: IDO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: D7Z7U
Application*: WB, IP, F
Target: IDO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: D8W5E
Application*: WB, IP, IF (IC)
Target: IDO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 8G11
Application*: F, WB
Target: IDO1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: mIDO-48
Application*: WB, P, C
Target: IDO1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7BA22
Application*: E
Target: IDO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A383
Application*: IF, IHC, IP, WB
Target: IDO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR031F
Application*: WB, IHC, ICC, IHC-IF
Target: IDO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR040F
Application*: WB, IP
Target: IDO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D5J4E
Application*: WB, IP, IH, P, IF (IC), F
Target: IDO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C9
Application*: WB, E
Target: IDO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F3
Application*: WB, E
Target: IDO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C1
Application*: E, E
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2147
Application*: IH
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1932
Application*: WB, IF
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1890
Application*: WB, IH, IF
Target: IDO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I1770
Application*: WB
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 9i171
Application*: WB, IH
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 700838
Application*: IS, IC, MC
Target: IDO1
Host: Mouse
Specificity: Human
Clone: 4F9
Application*: E, WB
Target: IDO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4D2
Application*: E, P, WB
Target: IDO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0485
Application*: IC, IF, P
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ID 177
Application*: E, WB, P
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-I0092
Application*: IS
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 2E2.6
Application*: E, F, IF, IP, WB, P
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B5
Application*: WB, IH, IF, P
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A3
Application*: IF, P, WB
Target: IDO1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Mouse, Human
Clone: 10.1
Application*: E, IH, IF, IP, WB, C
Target: IDO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0010
Application*: F
Target: IDO1
Specificity: Human
Target: IDO1
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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