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Mouse Anti-IFITM1 Recombinant Antibody (CBXC-0655) (CBMAB-C4379-CQ)

This product is a mouse antibody that recognizes IFITM1. The antibody CBXC-0655 can be used for immunoassay techniques such as: ELISA, WB.
See all IFITM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0655
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interferon Induced Transmembrane Protein 1
Introduction
IFITM1 (Interferon Induced Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with IFITM1 include Influenza and West Nile Virus. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor. An important paralog of this gene is IFITM3.
Entrez Gene ID
8519
UniProt ID
P13164
Alternative Names
Interferon Induced Transmembrane Protein 1
Function
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927).

Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927).

Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876).

Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436).

IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436).
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Defense response to virus Source: GO_Central
Negative regulation of cell migration Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Negative regulation of viral genome replication Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of osteoblast differentiation Source: UniProtKB
Response to interferon-alpha Source: UniProtKB
Response to interferon-beta Source: UniProtKB
Response to interferon-gamma Source: UniProtKB
Response to virus Source: UniProtKB
Type I interferon signaling pathway Source: GO_Central
Cellular Location
Lysosome membrane; Cell membrane
Topology
Cytoplasmic: 1-36
Helical: 37-57
Cytoplasmic: 58-86
Helical: 87-107
Extracellular: 108-125
PTM
Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity.

She, X., Shen, S., Chen, G., Gao, Y., Ma, J., Gao, Y., ... & Gao, H. (2023). Immune surveillance of brain metastatic cancer cells is mediated by IFITM1. The EMBO Journal, 42(7), e111112.

Zhang, W., Chen, S., Du, Q., Bian, P., Chen, Y., Liu, Z., ... & Jiang, X. (2022). CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1. Oncogene, 41(11), 1550-1562.

Provance, O. K., Geanes, E. S., Lui, A. J., Roy, A., Holloran, S. M., Gunewardena, S., ... & Lewis-Wambi, J. (2021). Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression. Cancer letters, 514, 12-29.

Li, H., Chen, Y. K., Wan, Q., Shi, A. Q., Wang, M., He, P., & Tang, L. X. (2021). Long non-coding RNA LINC00847 induced by E2F1 accelerates non-small cell lung cancer progression through targeting miR-147a/IFITM1 axis. Frontiers in medicine, 8, 663558.

Sun, H., Fukuda, S., Hirata, T., Arakawa, T., Ma, S., Neriishi, K., ... & Osuga, Y. (2020). IFITM1 is a novel, highly sensitive marker for endometriotic stromal cells in ovarian and extragenital endometriosis. Reproductive Sciences, 27, 1595-1601.

Wang, J., Wang, C. F., Ming, S. L., Li, G. L., Zeng, L., Wang, M. D., ... & Chu, B. B. (2020). Porcine IFITM1 is a host restriction factor that inhibits pseudorabies virus infection. International journal of biological macromolecules, 151, 1181-1193.

Liang, R., Li, X., & Zhu, X. (2020). Deciphering the roles of IFITM1 in tumors. Molecular Diagnosis & Therapy, 24, 433-441.

Sun, F., Xia, Z., Han, Y., Gao, M., Wang, L., Wu, Y., ... & Cao, Z. (2020). Topology, antiviral functional residues and mechanism of IFITM1. Viruses, 12(3), 295.

Gómez-Herranz, M., Nekulova, M., Faktor, J., Hernychova, L., Kote, S., Sinclair, E. H., ... & Hupp, T. R. (2019). The effects of IFITM1 and IFITM3 gene deletion on IFNγ stimulated protein synthesis. Cellular signalling, 60, 39-56.

Yang, J., Li, L., Xi, Y., Sun, R., Wang, H., Ren, Y., ... & Li, X. (2018). Combination of IFITM1 knockdown and radiotherapy inhibits the growth of oral cancer. Cancer science, 109(10), 3115-3128.

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For research use only. Not intended for any clinical use.

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