Mouse Anti-IFITM2 Recombinant Antibody (A386) (CBMAB-AP10811LY)

Name: Mouse Anti-IFITM2 Recombinant Antibody (A386)
SKU: CBMAB-AP10811LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A386

Application

ELISA, WB

Immunogen

Fusion protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interferon Induced Transmembrane Protein 2

Introduction

IFITM2 (Interferon Induced Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with IFITM2 include Influenza and Dengue Virus. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is IFITM3.

Entrez Gene ID

10581

UniProt ID

Q01629

Alternative Names

Interferon Induced Transmembrane Protein 2

Function

E-AB-27199

Biological Process

Cellular response to interferon-beta Source: UniProtKB
Defense response to virus Source: GO_Central
Immune response Source: ProtInc
Negative regulation of viral entry into host cell Source: UniProtKB
Negative regulation of viral genome replication Source: UniProtKB
Response to interferon-alpha Source: UniProtKB
Response to interferon-beta Source: UniProtKB
Response to interferon-gamma Source: UniProtKB
Response to virus Source: UniProtKB
Type I interferon signaling pathway Source: GO_Central

Cellular Location

Late endosome membrane; Lysosome membrane; Cell membrane

Topology

Cytoplasmic: 1-56
Helical: 57-77
Cytoplasmic: 78-106
Helical: 107-127
Extracellular: 128-132

PTM

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity.
Phosphorylation at Tyr-19 is required for endosomal and lysosomal location.

Basile, A., Zannella, C., De Marco, M., Sanna, G., Franci, G., Galdiero, M., ... & Marzullo, L. (2023). Spike-mediated viral membrane fusion is inhibited by a specific anti-IFITM2 monoclonal antibody. Antiviral Research, 211, 105546.

Chen, L., Li, X., Deng, Y., Bi, Y., Yan, Z., Yang, Y., ... & Feng, R. (2023). IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway. Viruses, 15(4), 866.

Nchioua, R., Schundner, A., Kmiec, D., Prelli Bozzo, C., Zech, F., Koepke, L., ... & Kirchhoff, F. (2022). SARS-CoV-2 variants of concern hijack IFITM2 for efficient replication in human lung cells. Journal of Virology, 96(11), e00594-22.

Wang, H., Wang, L., Luo, X., Guan, J., Zhang, X., Zhang, L., & Xiang, Y. (2022). Molecular characterization, expression and anti-tumor function analysis of yak IFITM2 gene. International Journal of Biological Macromolecules, 209, 405-412.

Basile, A., Zannella, C., De Marco, M., Franci, G., Galdiero, M., Sanna, G., ... & Marzullo, L. (2022). A specific anti-IFITM2 antibody bars the way to SARS-CoV-2 entry into host cells. bioRxiv, 2022-08.

Winstone, H., Lista, M. J., Reid, A. C., Bouton, C., Pickering, S., Galao, R. P., ... & Neil, S. J. (2021). The polybasic cleavage site in SARS-CoV-2 spike modulates viral sensitivity to type I interferon and IFITM2. Journal of virology, 95(9), 10-1128.

Yang, N., Liu, Z., Pang, S., Wu, J., Liang, J., & Sun, L. (2021). Predicative value of IFITM2 in renal clear cell carcinoma: IFITM2 is associated with lymphatic metastasis and poor clinical outcome. Biochemical and biophysical research communications, 534, 157-164.

Xie, J., Bi, Y., Xu, S., Han, Y., Idris, A., Zhang, H., ... & Feng, R. (2020). Host antiviral protein IFITM2 restricts pseudorabies virus replication. Virus research, 287, 198105.

Alam, U., & Kennedy, D. (2019). G3BP1 and G3BP2 regulate translation of interferon-stimulated genes: IFITM1, IFITM2 and IFITM3 in the cancer cell line MCF7. Molecular and Cellular Biochemistry, 459(1-2), 189-204.

Wang, H., Chen, L., Luo, J., & He, H. (2019). NP and NS1 proteins of H5N1 virus significantly upregulated IFITM1, IFITM2, and IFITM3 in A549 cells. African Health Sciences, 19(1), 1402-1410.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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