Recombinant Mouse Anti-IFNA1 Recombinant Antibody (ST126) (CBMAB-XB0583-YC)

Provided herein is a Mouse Recombinant Antibody against Interferon Alpha 1. The antibody can be used for immunoassay techniques, such as FuncS.
See all IFNA1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

ST126

Antibody Isotype

IgG2b

Application

FuncS

Basic Information

Immunogen

Human interferon (HuIFN) produced by Namalwa cells (HuIFN-aN)

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Interferon Alpha 1

Introduction

IFNA1 is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted.

Entrez Gene ID

3439

UniProt ID

P01562

Alternative Names

Interferon Alpha 1

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Biological Process

Adaptive immune response Source: GO_Central
B cell differentiation Source: GO_Central
B cell proliferation Source: GO_Central
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB-KW
Humoral immune response Source: GO_Central
Natural killer cell activation involved in immune response Source: GO_Central
Positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
Response to exogenous dsRNA Source: GO_Central
T cell activation involved in immune response Source: GO_Central

Cellular Location

Secreted

References

Jeon, K., Kim, Y., Kang, S. K., Park, U., Kim, J., Park, N., ... & Cho, N. H. (2023). Elevated IFNA1 and suppressed IL12p40 associated with persistent hyperinflammation in COVID-19 pneumonia. Frontiers in Immunology, 14, 1101808.

Wang, S., Chen, S. N., Sun, Z., Pang, A. N., Wang, S., Liu, L. H., ... & Nie, P. (2021). Four type I IFNs, IFNa1, IFNa2, IFNb, IFNc, and their receptor usage in an osteoglossomorph fish, the Asian arowana, Scleropages formosus. Fish & Shellfish Immunology, 117, 70-81.

Liu, J., Li, H., Lan, T., & Wang, W. (2021). IFNA1 and IFNA13 Genes Confer Genetic Predisposition to Ankylosing Spondylitis-Associated Uveitis in a Chinese Population. Current Eye Research, 46(4), 585-591.

He, Y. L., Yang, J., Zeng, Z. N., & Shi, X. (2020). Interaction of miR-181b and IFNA1 polymorphisms on the risk of systemic lupus erythematosus. BioMed Research International, 2020.

Yang, D. W., Zhang, X., Qian, G. B., Jiang, M. J., Wang, P., & Wang, K. Z. (2019). Downregulation of long noncoding RNA LOC101928134 inhibits the synovial hyperplasia and cartilage destruction of osteoarthritis rats through the activation of the Janus kinase/signal transducers and activators of transcription signaling pathway by upregulating IFNA1. Journal of Cellular Physiology, 234(7), 10523-10534.

Jiang, S., Sakamoto, R., & Kimura, T. (2019). A guinea pig IFNA1 gene with antiviral activity against human influenza virus infection. Frontiers in Bioscience-Landmark, 24(4), 790-797.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Antibody Pairs

IFNA1 Matched Antibody Pair (599)

Related Products

IFNA1 Matched Antibody Pair (599)

Mouse Anti-IFNA1 Recombinant Antibody (CBYY-I1154)

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Mouse Anti-IFNA1 Recombinant Antibody (CBYY-I0096)

Mouse Anti-IFNA1 Recombinant Antibody (8C21)

Recombinant Mouse Anti-IFNA1 Recombinant Antibody (ST47)

Recombinant Mouse Anti-IFNA1 Recombinant Antibody (ST225)

Rat Anti-IFNA1 Recombinant Antibody (4E-A1)

Rat Anti-IFNA1 Recombinant Antibody (CBYY-I1139)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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