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Mouse Anti-IFNL1 Recombinant Antibody (A543) (CBMAB-AP10866LY)

The product is antibody recognizes IFNL1. The antibody A543 immunoassay techniques such as: ELISA, WB.
See all IFNL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A543
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Fusion protein of IL-29
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interferon Lambda 1
Introduction
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Entrez Gene ID
282618
UniProt ID
Q8IU54
Alternative Names
Interferon Lambda 1
Function
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Biological Process
Defense response to virus Source: UniProtKB
Innate immune response Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of interleukin-13 production Source: UniProtKB
Negative regulation of interleukin-5 production Source: UniProtKB
Negative regulation of memory T cell differentiation Source: UniProtKB
Negative regulation of T cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of type 2 immune response Source: UniProtKB
Positive regulation of immune response Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of MHC class I biosynthetic process Source: UniProtKB
Positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Receptor signaling pathway via JAK-STAT Source: InterPro
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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