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Rat Anti-IGFALS Recombinant Antibody (4K23) (CBMAB-A4463-YC)

Provided herein is a Rat monoclonal antibody against Mouse Insulin Like Growth Factor Binding Protein Acid Labile Subunit. The antibody can be used for immunoassay techniques, such as WB.
See all IGFALS antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
4K23
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Insulin Like Growth Factor Binding Protein Acid Labile Subunit
Introduction
IGFALS is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this g
Entrez Gene ID
16005
UniProt ID
P70389
Alternative Names
mKIAA4111; Albs; ALS
Function
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
Biological Process
Cell adhesion Source: UniProtKB-KW
Signal transduction Source: ProtInc
Cellular Location
Extracellular space
Involvement in disease
Acid-labile subunit deficiency (ACLSD):
A disorder characterized by severely reduced serum IGF-I and IGFBP-3 concentrations and mild growth retardation. Pubertal delay in boys and insulin insensitivity are common findings.

Franzoni, A., Baldan, F., Passon, N., Mio, C., Driul, D., Cogo, P., ... & Damante, G. (2023). Novel IGFALS mutations with predicted pathogenetic effects by the analysis of AlphaFold structure. Endocrine, 79(2), 292-295.

Genç, R., & Sönmez, Z. (2023). IGFALS Gene Polymorphisms in Simmental Breed Cattle. Turkish Journal of Agriculture-Food Science and Technology, 11(4), 846-850.

Bayraktar, M., & Shoshin, O. (2022). Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep. Brazilian Archives of Biology and Technology, 64.

Zhang, Y. Y., Jing, C. A. O., Xiao-Tong, C. H. E. N., Jun-Hui, C. H. E. N., & Zheng, Y. B. (2021). Liver tissue-specific genes Igfals, Cyp3a4, Slc22a1 and Cyp2e1 may be associated with poor prognosis of liver cancer. Acta Academiae Medicinae Sinicae, 371-381.

Xu, G., Deng, F., Zuo, Q., Liu, L., Dou, K., Cheng, Z., ... & Zhu, Y. (2021). Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation. Cellular & Molecular Immunology, 18(6), 1587-1589.

Fadel, I. M., Ragab, M. H., Eid, O. M., Helmy, N. A., El-Bassyouni, H. T., & Mazen, I. (2021). IGF1R, IGFALS, and IGFBP3 gene copy number variations in a group of non-syndromic Egyptian short children. Journal of Genetic Engineering and Biotechnology, 19(1), 1-7.

Kumar, A., Jain, V., Chowdhury, M. R., Kumar, M., Kaur, P., & Kabra, M. (2020). Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature. Journal of Pediatric Endocrinology and Metabolism, 33(1), 79-88.

Alizadeh, F., Moradian, F., & Farhadi, A. (2020). Association of allelic polymorphisms of IGFALS gene with growth traits in Makouei and Ghezel sheep breeds. Tropical Animal Health and Production, 52, 3027-3034.

Poyrazoğlu, Ş., Hwa, V., Baş, F., Dauber, A., Rosenfeld, R., & Darendeliler, F. (2019). A novel homozygous mutation of the acid-labile subunit (IGFALS) gene in a male adolescent. Journal of Clinical Research in Pediatric Endocrinology, 11(4), 432.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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