Mouse Anti-IGHA1 Recombinant Antibody (IA761) (CBMAB-I0180-YY)

Name: Mouse Anti-IGHA1 Recombinant Antibody (IA761)
SKU: CBMAB-I0180-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

IA761

Application

IHC-P, IF, FC

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.05% BSA, 10mM PBS

Preservative

0.05% azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Immunoglobulin Heavy Constant Alpha 1

Introduction

IGHA1 (Immunoglobulin Heavy Constant Alpha 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall.

Entrez Gene ID

3493

UniProt ID

P01876

Alternative Names

Immunoglobulin Heavy Constant Alpha 1

Function

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).

The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).

Biological Process

Antibacterial humoral response Source: UniProtKB
B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Glomerular filtration Source: UniProtKB
Immune response Source: UniProtKB
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central
Positive regulation of respiratory burst Source: UniProtKB
Protein-chromophore linkage Source: UniProtKB-KW
Retina homeostasis Source: UniProtKB

Cellular Location

Secreted; Cell membrane

Involvement in disease

A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

PTM

3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.

Maruyama, Y., Seki, T., Ando, S., Tanabe, H., & Mori, H. (2023). Analysis of IGHA1 and other salivary proteins post half marathon in female participants. PeerJ, 11, e15075.

LI, R., Wang, M., Xie, X., Tian, W., Zhang, Y., Li, J., ... & Zhang, H. (2023). WCN23-1024 Elevated Human IgA1 Expression and O-glycosylation Change with Increased Pathogen Exposure on IGHA1 Knock-in Mouse Model. Kidney International Reports, 8(3), S226-S227.

Chitnis, N. S., Hu, T., Duke, J., Henrickson, S., Silverman, M., Kamoun, M., ... & Monos, D. S. (2018). P089 Suppression of a HLA-B encoded microrna upregulates the expression of heavy chain IGA (IGHA1) transcript in human primary B-cells. Human Immunology, 79, 127.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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