IGHA1
IGHA1 (Immunoglobulin Heavy Constant Alpha 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include antigen binding and immunoglobulin receptor binding. An important paralog of this gene is IGHA2.
Full Name
Immunoglobulin Heavy Constant Alpha 1
Function
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).
The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
Biological Process
Antibacterial humoral response Source: UniProtKB
B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Glomerular filtration Source: UniProtKB
Immune response Source: UniProtKB
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central
Positive regulation of respiratory burst Source: UniProtKB
Protein-chromophore linkage Source: UniProtKB-KW
Retina homeostasis Source: UniProtKB
Cellular Location
Secreted; Cell membrane
Involvement in disease
A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
PTM
3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.
Loading...
Datasheet