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Armenian hamster Anti-IKZF2 Recombinant Antibody (CBWJZ-257) (CBMAB-Z0683-WJ)

This product is a armenian hamster antibody that recognizes IKZF2. The antibody CBWJZ-257 can be used for immunoassay techniques such as: FC.
See all IKZF2 antibodies

Summary

Host Animal
Armenian hamster
Specificity
Mouse, Human
Clone
CBWJZ-257
Antibody Isotype
IgG
Application
FC

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
IKAROS family zinc finger 2
Introduction
IKZF2 (IKAROS Family Zinc Finger 2) is a Protein Coding gene encodes a member of the Ikaros family of zinc-finger proteins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein heterodimerization activity. An important paralog of this gene is IKZF4.
Entrez Gene ID
Human22807
Mouse22779
UniProt ID
HumanQ9UKS7
MouseP81183
Alternative Names
ANF1A2; HELIOS; ZNF1A2; ZNFN1A2
Function
Associates with Ikaros at centromeric heterochromatin.
Biological Process
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Bonazzi, S., d’Hennezel, E., Beckwith, R. E., Xu, L., Fazal, A., Magracheva, A., ... & Solomon, J. M. (2023). Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chemical Biology, 30(3), 235-247.

Li, S., He, S., Lu, Y., Jia, S., & Liu, Z. (2023). Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development. Cell Reports, 42(5).

Park, S. M., Miyamoto, D. K., Han, G. Y., Chan, M., Curnutt, N. M., Tran, N. L., ... & Woo, C. M. (2023). Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells. Cancer Cell, 41(4), 726-739.

Mohajeri, A., Vaseghi-Shanjani, M., Rosenfeld, J. A., Yang, G. X., Lu, H., Sharma, M., ... & Care4Rare Canada Consortium. (2023). Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay. Journal of Medical Genetics.

Shahin, T., Mayr, D., Shoeb, M. R., Kuehn, H. S., Hoeger, B., Giuliani, S., ... & Boztug, K. (2022). Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation. Blood advances, 6(7), 2444-2451.

Solomon, J., Bonazzi, S., d'Hennezel, E., Beckwith, R., Xu, L., Fazal, A., ... & Visser, M. (2022). Targeted degradation of IKZF2 for cancer immunotherapy.

Park, S. M., Miyamoto, D., Han, G., Chan, M., Curnutt, N., Tran, N., ... & Kharas, M. G. (2022). Dual IKZF2 and CK1α Degrader Targets Acute Myeloid Leukemia Cells. Blood, 140(Supplement 1), 675-676.

Hetemäki, I., Kaustio, M., Kinnunen, M., Heikkilä, N., Keskitalo, S., Nowlan, K., ... & Kekäläinen, E. (2021). Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Science immunology, 6(65), eabe3454.

Sun, S., Li, S., Luo, Z., Ren, M., He, S., Wang, G., & Liu, Z. (2021). Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells. Elife, 10, e66547.

Park, S. M., Cho, H., Thornton, A. M., Barlowe, T. S., Chou, T., Chhangawala, S., ... & Kharas, M. G. (2019). IKZF2 drives leukemia stem cell self-renewal and inhibits myeloid differentiation. Cell stem cell, 24(1), 153-165.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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