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Rabbit Anti-IKZF2 Recombinant Antibody (D4Z6D) (CBMAB-CP0932-LY)

The product is antibody recognizes IKZF2. The antibody D4Z6D immunoassay techniques such as: WB,IP,FC,CIP.
See all IKZF2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D4Z6D
Antibody Isotype
IgG
Application
WB, IP, FC, CIP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro424 of human Helios protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
IKAROS family zinc finger 2
Introduction
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Entrez Gene ID
22807
UniProt ID
Q9UKS7
Alternative Names
IKAROS Family Zinc Finger 2
Function
Associates with Ikaros at centromeric heterochromatin.
Biological Process
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Bonazzi, S., d’Hennezel, E., Beckwith, R. E., Xu, L., Fazal, A., Magracheva, A., ... & Solomon, J. M. (2023). Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chemical Biology, 30(3), 235-247.

Li, S., He, S., Lu, Y., Jia, S., & Liu, Z. (2023). Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development. Cell Reports, 42(5).

Park, S. M., Miyamoto, D. K., Han, G. Y., Chan, M., Curnutt, N. M., Tran, N. L., ... & Woo, C. M. (2023). Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells. Cancer Cell, 41(4), 726-739.

Mohajeri, A., Vaseghi-Shanjani, M., Rosenfeld, J. A., Yang, G. X., Lu, H., Sharma, M., ... & Care4Rare Canada Consortium. (2023). Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay. Journal of Medical Genetics.

Shahin, T., Mayr, D., Shoeb, M. R., Kuehn, H. S., Hoeger, B., Giuliani, S., ... & Boztug, K. (2022). Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation. Blood advances, 6(7), 2444-2451.

Solomon, J., Bonazzi, S., d'Hennezel, E., Beckwith, R., Xu, L., Fazal, A., ... & Visser, M. (2022). Targeted degradation of IKZF2 for cancer immunotherapy.

Park, S. M., Miyamoto, D., Han, G., Chan, M., Curnutt, N., Tran, N., ... & Kharas, M. G. (2022). Dual IKZF2 and CK1α Degrader Targets Acute Myeloid Leukemia Cells. Blood, 140(Supplement 1), 675-676.

Hetemäki, I., Kaustio, M., Kinnunen, M., Heikkilä, N., Keskitalo, S., Nowlan, K., ... & Kekäläinen, E. (2021). Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Science immunology, 6(65), eabe3454.

Sun, S., Li, S., Luo, Z., Ren, M., He, S., Wang, G., & Liu, Z. (2021). Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells. Elife, 10, e66547.

Park, S. M., Cho, H., Thornton, A. M., Barlowe, T. S., Chou, T., Chhangawala, S., ... & Kharas, M. G. (2019). IKZF2 drives leukemia stem cell self-renewal and inhibits myeloid differentiation. Cell stem cell, 24(1), 153-165.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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