Mouse Anti-IKZF4 Recombinant Antibody (CBWJZ-261) (CBMAB-Z0686-WJ)

Name: Mouse Anti-IKZF4 Recombinant Antibody (CBWJZ-261)
SKU: CBMAB-Z0686-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJZ-261

Application

Specificity

Human

Antibody Isotype

IgM

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

IKAROS family zinc finger 4

Introduction

IKZF4 (IKAROS Family Zinc Finger 4) is a Protein Coding gene. Diseases associated with IKZF4 include Alopecia Areata. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is IKZF2.

Entrez Gene ID

64375

UniProt ID

Q9H2S9

Alternative Names

EOS; ZNFN1A4

Function

DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).

Biological Process

Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Protein homooligomerization Source: CAFA
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Wang, Y., Zhao, H., He, Y., Zhang, P., Zeng, C., Du, T., ... & Zhao, S. (2023). IKZF4 acts as a novel tumor suppressor in non–small cell lung cancer by suppressing Notch signaling pathway. Cellular Signalling, 107, 110679.

Miao, Y., Hu, R., Sheng, Y., Qi, S., & Yang, Q. (2022). Association analysis of IKZF4 gene with alopecia areata in Chinese Han population.

Vandewalle, J., Van der Auwera, B. J., Amin, H., Quartier, E., Desouter, A. K., Tenoutasse, S., ... & Belgian Diabetes Registry. (2021). Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives. Diabetologia, 64, 2511-2516.

Gokhale, A. S., Gangaplara, A., Lopez-Occasio, M., Thornton, A. M., & Shevach, E. M. (2020). Corrigendum to “Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity”[J. Autoimmun. 105C (2019) 102300](Journal of Autoimmunity (2019) 105,(S089684111930280X),(10.1016/j. jaut. 2019.06. 011)). Journal of Autoimmunity, 114, 102544.

Gokhale, A. S., Gangaplara, A., Lopez-Occasio, M., Thornton, A. M., & Shevach, E. M. (2019). Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity. Journal of Autoimmunity, 105, 102300.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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