Rabbit Anti-IKZF4 Recombinant Antibody (EG1630) (CBMAB-EN1951-LY)

Name: Rabbit Anti-IKZF4 Recombinant Antibody (EG1630)
SKU: CBMAB-EN1951-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG1630

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human IKZF4.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

IKAROS family zinc finger 4

Introduction

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.

Entrez Gene ID

Human	64375
Mouse	22781
Rat	100361923

UniProt ID

Human	Q9H2S9
Mouse	Q8C208
Rat	D4A636

Alternative Names

EOS; ZNFN1A4

Function

DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).

Biological Process

Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Protein homooligomerization Source: CAFA
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

More Infomation

References

Wang, Y., Zhao, H., He, Y., Zhang, P., Zeng, C., Du, T., ... & Zhao, S. (2023). IKZF4 acts as a novel tumor suppressor in non–small cell lung cancer by suppressing Notch signaling pathway. Cellular Signalling, 107, 110679.

Miao, Y., Hu, R., Sheng, Y., Qi, S., & Yang, Q. (2022). Association analysis of IKZF4 gene with alopecia areata in Chinese Han population.

Vandewalle, J., Van der Auwera, B. J., Amin, H., Quartier, E., Desouter, A. K., Tenoutasse, S., ... & Belgian Diabetes Registry. (2021). Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives. Diabetologia, 64, 2511-2516.

Gokhale, A. S., Gangaplara, A., Lopez-Occasio, M., Thornton, A. M., & Shevach, E. M. (2020). Corrigendum to “Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity”[J. Autoimmun. 105C (2019) 102300](Journal of Autoimmunity (2019) 105,(S089684111930280X),(10.1016/j. jaut. 2019.06. 011)). Journal of Autoimmunity, 114, 102544.

Gokhale, A. S., Gangaplara, A., Lopez-Occasio, M., Thornton, A. M., & Shevach, E. M. (2019). Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity. Journal of Autoimmunity, 105, 102300.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-IKZF4 Recombinant Antibody (CBWJZ-261)

Mouse Anti-IKZF4 Recombinant Antibody (CBYY-I0919)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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