Human Anti-IL12RB2 Recombinant Antibody (CBYY-I0413) (CBMAB-I1011-YY)

Name: Human Anti-IL12RB2 Recombinant Antibody (CBYY-I0413)
SKU: CBMAB-I1011-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Human

Clone

CBYY-I0413

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.05% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

interleukin 12 receptor, beta 2

Introduction

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.

Entrez Gene ID

3595

UniProt ID

Q99665

Alternative Names

Interleukin 12 Receptor Subunit Beta 2

Function

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Cytokine-mediated signaling pathway Source: GO_Central
Peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of interferon-gamma production Source: BHF-UCL
Positive regulation of natural killer cell proliferation Source: ComplexPortal
Positive regulation of NK T cell proliferation Source: ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortal
Positive regulation of T cell proliferation Source: ComplexPortal
Response to lipopolysaccharide Source: Ensembl

Cellular Location

Membrane

Topology

Extracellular: 24-622
Helical: 623-643
Cytoplasmic: 644-862

PTM

On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.

Zagoriti, Z., Lagoumintzis, G., Perroni, G., Papathanasiou, G., Papadakis, A., Ambrogi, V., ... & Poulas, K. (2018). Evidence for association of STAT4 and IL12RB2 variants with Myasthenia gravis susceptibility: What is the effect on gene expression in thymus?. Journal of Neuroimmunology, 319, 93-99.

Kramer, M., Hasanreisoglu, M., Weiss, S., Kumova, D., Schaap-Fogler, M., Guntekin-Ergun, S., ... & Cohen, Y. (2018). Single-nucleotide polymorphisms in IL23R-IL12RB2 (rs1495965) are highly prevalent in patients with Behcet’s uveitis and vary between populations. Ocular Immunology and Inflammation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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