IL12RB2

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]
Full Name
interleukin 12 receptor, beta 2
Function
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Cytokine-mediated signaling pathway Source: GO_Central
Peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of interferon-gamma production Source: BHF-UCL
Positive regulation of natural killer cell proliferation Source: ComplexPortal
Positive regulation of NK T cell proliferation Source: ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortal
Positive regulation of T cell proliferation Source: ComplexPortal
Response to lipopolysaccharide Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 24-622
Helical: 623-643
Cytoplasmic: 644-862
PTM
On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
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Anti-IL12RB2 antibodies

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Mouse Anti-IL12RB2 Recombinant Antibody (CBYY-I1411) (CBMAB-I2581-YY)

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Target: IL12RB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-I1411
Application*: F
Datasheet SDS

Rabbit Anti-IL12RB2 Recombinant Antibody (CBYY-I1376) (CBMAB-I2546-YY)

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Target: IL12RB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-I1376
Application*: E
Datasheet SDS

Rat Anti-IL12RB2 Recombinant Antibody (CBYY-I0807) (CBMAB-I1797-YY)

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Target: IL12RB2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0807
Application*: BL
Datasheet SDS

Mouse Anti-IL12RB2 Recombinant Antibody (CBYY-I0683) (CBMAB-I1506-YY)

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Target: IL12RB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0683
Application*: WB
Datasheet SDS

Human Anti-IL12RB2 Recombinant Antibody (CBYY-I0413) (CBMAB-I1011-YY)

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Target: IL12RB2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0413
Application*: F
Datasheet SDS

Mouse Il12rb2 ELISA Kit (V2LY-0626-LY5794)

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Target: Il12rb2
Sensitivity: 0.027 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Mouse Recombinant IL12RB2 protein, His Tag (V2LY-0526-LY8473)

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Target: IL12RB2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-637
Tag: His Tag
Datasheet SDS

Human Recombinant IL12RB2 protein, His Tag (V2LY-0526-LY4737)

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Target: IL12RB2
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-622
Tag: His Tag
Datasheet SDS

Human Recombinant IL12RB2 protein, ECD, His Tag (V2LY-0526-LY4736)

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Target: IL12RB2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 24-622
Tag: His Tag
Datasheet SDS

Cynomolgus Recombinant IL12RB2 protein, ECD, Fc Tag (V2LY-0526-LY1548)

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Target: IL12RB2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 24-623
Tag: Fc Tag
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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