IL12RB2
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]
Full Name
interleukin 12 receptor, beta 2
Function
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Cytokine-mediated signaling pathway Source: GO_Central
Peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of interferon-gamma production Source: BHF-UCL
Positive regulation of natural killer cell proliferation Source: ComplexPortal
Positive regulation of NK T cell proliferation Source: ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortal
Positive regulation of T cell proliferation Source: ComplexPortal
Response to lipopolysaccharide Source: Ensembl
Cytokine-mediated signaling pathway Source: GO_Central
Peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of interferon-gamma production Source: BHF-UCL
Positive regulation of natural killer cell proliferation Source: ComplexPortal
Positive regulation of NK T cell proliferation Source: ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STAT Source: ComplexPortal
Positive regulation of T cell proliferation Source: ComplexPortal
Response to lipopolysaccharide Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 24-622
Helical: 623-643
Cytoplasmic: 644-862
Helical: 623-643
Cytoplasmic: 644-862
PTM
On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
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Anti-IL12RB2 antibodies
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CompareTarget: IL12RB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-I1411
Application*: F
Target: IL12RB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-I1376
Application*: E
Target: IL12RB2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I0807
Application*: BL
Target: IL12RB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0683
Application*: WB
Target: IL12RB2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0413
Application*: F
Target: IL12RB2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-637
Tag: His Tag
Target: IL12RB2
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-622
Tag: His Tag
Target: IL12RB2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 24-622
Tag: His Tag
Target: IL12RB2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 24-623
Tag: Fc Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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