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Mouse Anti-IL13RA2 (AA 22-342) Recombinant Antibody (CBYY-I0771) (CBMAB-I1715-YY)

This product is Mouse antibody that recognizes IL13RA2. The antibody CBYY-I0771 can be used for immunoassay techniques such as: ELISA(Cap)
See all IL13RA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I0771
Antibody Isotype
IgG1
Application
ELISA(Cap)

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA22-342

Target

Full Name
Interleukin 13 Receptor Subunit Alpha 2
Introduction
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.
Entrez Gene ID
3598
UniProt ID
Q14627
Alternative Names
Interleukin 13 Receptor Subunit Alpha 2
Function
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
Biological Process
Cytokine-mediated signaling pathway Source: GO_Central
Immunoglobulin mediated immune response Source: Ensembl
Negative regulation of immunoglobulin production Source: Ensembl
Negative regulation of mast cell degranulation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 27-343
Helical: 344-363
Cytoplasmic: 364-380

Subham, S., Jeppson, J. D., Schatmeyer, B., Forman, S. J., Brown, C. E., & Akhavan, D. (2023). Protein kinase C is an upstream regulator of IL13Ra2 and small molecular activator enhances CAR T mediated killing. Cancer Research, 83(7_Supplement), 3235-3235.

Hotblack, A., Wawrzyniecka, P., Cheng, G. W. K., Nannini, F., Pule, M., & Straathof, K. (2022). IMMU-16. Next-generation CAR T-cells targeting IL13RA2 and secreting IL-15 achieve durable tumour clearance in pre-clinical model of diffuse midline glioma. Neuro-Oncology, 24(Suppl 1), i85.

Rossmeisl, J. H., Herpai, D., Quigley, M., Cecere, T. E., Robertson, J. L., D’Agostino, R. B., ... & Debinski, W. (2021). Phase I trial of convection-enhanced delivery of IL13RA2 and EPHA2 receptor targeted cytotoxins in dogs with spontaneous intracranial gliomas. Neuro-oncology, 23(3), 422-434.

Zeng, J., Zhang, J., Yang, Y. Z., Wang, F., Jiang, H., Chen, H. D., ... & Hu, W. M. (2020). IL13RA2 is overexpressed in malignant gliomas and related to clinical outcome of patients. American Journal of Translational Research, 12(8), 4702.

Wang, M., Yao, R., & Wang, Y. (2020). Silencing of IL13RA2 promotes partial epithelial‐mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation. FEBS Open bio, 10(2), 229-236.

Verstockt, B., Verstockt, S., Creyns, B., Tops, S., Van Assche, G., Gils, A., ... & Breynaert, C. (2019). Mucosal IL13RA2 expression predicts nonresponse to anti‐TNF therapy in Crohn's disease. Alimentary Pharmacology & Therapeutics, 49(5), 572-581.

Chong, S. T., Tan, K. M., Kok, C. Y., Guan, S. P., Lai, S. H., Lim, C., ... & Ngeow, J. (2019). IL13RA2 is differentially regulated in papillary thyroid carcinoma vs follicular thyroid carcinoma. The Journal of Clinical Endocrinology & Metabolism, 104(11), 5573-5584.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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