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Mouse Anti-IL15RA Recombinant Antibody (CBT4217) (V2LY-0625-LY1245)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4217
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human CD215 (AA: extra 31-205) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
interleukin 15 receptor subunit alpha
Entrez Gene ID
3601
UniProt ID
Q13261
Function
High-affinity receptor for interleukin-15 (PubMed:8530383).

Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity).

In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770).

In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770).

Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910).

Isoform 5&6&7&8:
Does not bind IL15.
Biological Process
Interleukin-15-mediated signaling pathway Source: UniProtKB
Positive regulation of natural killer cell differentiation Source: Ensembl
Positive regulation of phagocytosis Source: UniProtKB
Cellular Location
Nucleus membrane; Membrane; Cell surface. Mainly found associated with the nuclear membrane.
Isoform 5: Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasmic vesicle membrane; Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 6: Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasmic vesicle membrane; Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 7: Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasmic vesicle membrane; Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 8: Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasmic vesicle membrane; Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Soluble interleukin-15 receptor subunit alpha: Extracellular space
Topology
Extracellular: 31-205
Helical: 206-228
Cytoplasmic: 229-267
PTM
N-glycosylated and O-glycosylated.
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (PubMed:15265897). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor (PubMed:15265897).
More Infomation

Liu, Z., Zou, W., Xu, Y., & Wu, P. (2023). Clinical characterization and immunosuppressive regulation of IL15RA in Kidney renal papillary cell carcinoma through 324 samples.

Fu, S., Kundranda, M. N., Rahimian, S., Shen, Y., Tan, Q., Zhao, R., ... & Liang, T. (2023). The initial report of phase I trial of VG2025, a non-attenuated HSV-1 oncolytic virus expressing IL-12 and IL-15/RA payloads, in patients with advanced solid tumors.

Bellón, T., González-Valle, O., Sendagorta, E., Lerma, V., Martínez del Río, J., Martínez, C., ... & de Abajo, F. (2022). IL-15/IL-15Rα in SJS/TEN: Relevant Expression of IL15 and IL15RA in Affected Skin. Biomedicines, 10(8), 1868.

De Mattia, E., Polesel, J., Roncato, R., Labriet, A., Bignucolo, A., Gagno, S., ... & Toffoli, G. (2021). IL15RA and SMAD3 genetic variants predict overall survival in metastatic colorectal cancer patients treated with folfiri therapy: A new paradigm. Cancers, 13(7), 1705.

Warner, S. C., Nair, A., Marpadga, R., Chubinskaya, S., Doherty, M., Valdes, A. M., & Scanzello, C. R. (2020). IL-15 and IL15RA in osteoarthritis: association with symptoms and protease production, but not structural severity. Frontiers in immunology, 11, 1385.

Yang, H., Zhou, L., Chen, J., Su, J., Shen, W., Liu, B., ... & Qian, J. (2019). A four‑gene signature for prognosis in breast cancer patients with hypermethylated IL15RA. Oncology Letters, 17(5), 4245-4254.

Loro, E., Bisetto, S., & Khurana, T. S. (2018). Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA. Journal of Cell Science, 131(21), jcs218313.

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For research use only. Not intended for any clinical use.

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