Human IL15RA ELISA Kit (V2LY-0626-LY4756)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.0099 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
28.2 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
interleukin 15 receptor subunit alpha
Function
High-affinity receptor for interleukin-15 (PubMed:8530383).

Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity).

In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770).

In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770).

Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910).

Isoform 5&6&7&8:
Does not bind IL15.
Biological Process
Interleukin-15-mediated signaling pathway Source: UniProtKB
Positive regulation of natural killer cell differentiation Source: Ensembl
Positive regulation of phagocytosis Source: UniProtKB
Cellular Location
Nucleus membrane; Membrane; Cell surface. Mainly found associated with the nuclear membrane.
Isoform 5: Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasmic vesicle membrane; Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 6: Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasmic vesicle membrane; Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 7: Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasmic vesicle membrane; Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 8: Golgi apparatus membrane; Endoplasmic reticulum membrane; Cytoplasmic vesicle membrane; Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Soluble interleukin-15 receptor subunit alpha: Extracellular space
Topology
Extracellular: 31-205
Helical: 206-228
Cytoplasmic: 229-267
PTM
N-glycosylated and O-glycosylated.
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (PubMed:15265897). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor (PubMed:15265897).

Liu, Z., Zou, W., Xu, Y., & Wu, P. (2023). Clinical characterization and immunosuppressive regulation of IL15RA in Kidney renal papillary cell carcinoma through 324 samples.

Fu, S., Kundranda, M. N., Rahimian, S., Shen, Y., Tan, Q., Zhao, R., ... & Liang, T. (2023). The initial report of phase I trial of VG2025, a non-attenuated HSV-1 oncolytic virus expressing IL-12 and IL-15/RA payloads, in patients with advanced solid tumors.

Bellón, T., González-Valle, O., Sendagorta, E., Lerma, V., Martínez del Río, J., Martínez, C., ... & de Abajo, F. (2022). IL-15/IL-15Rα in SJS/TEN: Relevant Expression of IL15 and IL15RA in Affected Skin. Biomedicines, 10(8), 1868.

De Mattia, E., Polesel, J., Roncato, R., Labriet, A., Bignucolo, A., Gagno, S., ... & Toffoli, G. (2021). IL15RA and SMAD3 genetic variants predict overall survival in metastatic colorectal cancer patients treated with folfiri therapy: A new paradigm. Cancers, 13(7), 1705.

Warner, S. C., Nair, A., Marpadga, R., Chubinskaya, S., Doherty, M., Valdes, A. M., & Scanzello, C. R. (2020). IL-15 and IL15RA in osteoarthritis: association with symptoms and protease production, but not structural severity. Frontiers in immunology, 11, 1385.

Yang, H., Zhou, L., Chen, J., Su, J., Shen, W., Liu, B., ... & Qian, J. (2019). A four‑gene signature for prognosis in breast cancer patients with hypermethylated IL15RA. Oncology Letters, 17(5), 4245-4254.

Loro, E., Bisetto, S., & Khurana, T. S. (2018). Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA. Journal of Cell Science, 131(21), jcs218313.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL15RA protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4760)

Human Recombinant IL15RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4761)

Human Recombinant IL15RA protein, ECD, His Tag (CAT#: V2LY-0526-LY4762)

Mouse Recombinant IL15RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8486)

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Mouse Anti-IL15RA Recombinant Antibody (CBYY-I0139) (CAT#: CBMAB-I0401-YY)

Rabbit Anti-IL15RA Recombinant Antibody (EG1633) (CAT#: CBMAB-EN1954-LY)

Human Recombinant IL15RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4761)

Mouse Anti-IL15RA Recombinant Antibody (CBT4217) (CAT#: V2LY-0625-LY1245)

Human Recombinant IL15RA protein, ECD, His Tag (CAT#: V2LY-0526-LY4762)

Human Recombinant IL15RA protein, ECD, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4760)

Mouse Recombinant IL15RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8486)

Mouse Anti-IL15RA Recombinant Antibody (151303) (CAT#: CBMAB-I0400-YY)

Isotype control

For research use only. Not intended for any clinical use.

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