Mouse Anti-IL17A Recombinant Antibody (A478) (CBMAB-AP4761LY)

Interleukin 17A

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

Interleukin 17A

E-AB-2191

Adaptive immune response Source: UniProtKB-KW
Apoptotic process Source: ProtInc
Cell-cell signaling Source: ProtInc
Cell death Source: ProtInc
Cellular response to interleukin-1 Source: Ensembl
Defense response to fungus Source: Ensembl
Defense response to Gram-negative bacterium Source: Ensembl
Defense response to Gram-positive bacterium Source: Ensembl
Fibroblast activation Source: BHF-UCL
Granulocyte migration Source: Ensembl
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Interleukin-17-mediated signaling pathway Source: UniProtKB
Intestinal epithelial structure maintenance Source: Ensembl
Notch signaling pathway Source: Ensembl
Positive regulation of antimicrobial peptide production Source: Ensembl
Positive regulation of bicellular tight junction assembly Source: Ensembl
Positive regulation of chemokine (C-X-C motif) ligand 1 production Source: UniProtKB
Positive regulation of cytokine production involved in inflammatory response Source: ARUK-UCL
Positive regulation of interleukin-12 production Source: ARUK-UCL
Positive regulation of interleukin-16 production Source: ARUK-UCL
Positive regulation of interleukin-1 beta production Source: ARUK-UCL
Positive regulation of interleukin-23 production Source: BHF-UCL
Positive regulation of interleukin-6 production Source: UniProtKB
Positive regulation of osteoclast differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of tumor necrosis factor production Source: ARUK-UCL

Secreted

N-glycosylated. Found both in glycosylated and nonglycosylated forms.