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Rat Anti-IL17A Recombinant Antibody (CBYY-I0144) (CBMAB-I0414-YY)

This product is Rat antibody that recognizes IL17A. The antibody CBYY-I0144 can be used for immunoassay techniques such as: ELISA, FuncS
See all IL17A antibodies

Summary

Host Animal
Rat
Specificity
Mouse, Rat
Clone
CBYY-I0144
Antibody Isotype
IgG2a, κ
Application
ELISA, FuncS

Basic Information

Specificity
Mouse, Rat
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
pH 7.2
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 17A
Introduction
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Entrez Gene ID
Mouse16171
Rat301289
UniProt ID
MouseQ62386
RatQ61453
Alternative Names
Interleukin 17A
Function
Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:24120361).

Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:19825828, PubMed:21350122, PubMed:17911633, PubMed:18684971, PubMed:8676080, PubMed:24120361).

Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity).

In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (By similarity).

In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity).

Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (By similarity).

Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (By similarity).

Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection (PubMed:21350122).

Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (By similarity).

As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (By similarity).

In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity).

Involved in antiviral host defense through various mechanisms (By similarity).

Enhances immunity against West Nile virus by promoting T cell cytotoxicity (By similarity).

May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (By similarity).

Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Apoptotic process Source: ProtInc
Cell-cell signaling Source: ProtInc
Cell death Source: ProtInc
Cellular response to interleukin-1 Source: Ensembl
Defense response to fungus Source: Ensembl
Defense response to Gram-negative bacterium Source: Ensembl
Defense response to Gram-positive bacterium Source: Ensembl
Fibroblast activation Source: BHF-UCL
Granulocyte migration Source: Ensembl
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Interleukin-17-mediated signaling pathway Source: UniProtKB
Intestinal epithelial structure maintenance Source: Ensembl
Notch signaling pathway Source: Ensembl
Positive regulation of antimicrobial peptide production Source: Ensembl
Positive regulation of bicellular tight junction assembly Source: Ensembl
Positive regulation of chemokine (C-X-C motif) ligand 1 production Source: UniProtKB
Positive regulation of cytokine production involved in inflammatory response Source: ARUK-UCL
Positive regulation of interleukin-12 production Source: ARUK-UCL
Positive regulation of interleukin-16 production Source: ARUK-UCL
Positive regulation of interleukin-1 beta production Source: ARUK-UCL
Positive regulation of interleukin-23 production Source: BHF-UCL
Positive regulation of interleukin-6 production Source: UniProtKB
Positive regulation of osteoclast differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of tumor necrosis factor production Source: ARUK-UCL
Cellular Location
Secreted
PTM
N-glycosylated. Found both in glycosylated and nonglycosylated forms.

Wang, Y., Wang, X., Li, Y., Xue, Z., Shao, R., Li, L., ... & Yang, J. (2022). Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway. Pharmacological research, 176, 106083.

Papp, K. A., Weinberg, M. A., Morris, A., & Reich, K. (2021). IL17A/F nanobody sonelokimab in patients with plaque psoriasis: a multicentre, randomised, placebo-controlled, phase 2b study. The Lancet, 397(10284), 1564-1575.

Roche, D., Badard, M., Boyer, L., Lafforgue, P., & Pham, T. (2021). Incidence of anterior uveitis in patients with axial spondyloarthritis treated with anti-TNF or anti-IL17A: a systematic review, a pairwise and network meta-analysis of randomized controlled trials. Arthritis Research & Therapy, 23, 1-11.

Mucciolo, G., Curcio, C., Roux, C., Li, W. Y., Capello, M., Curto, R., ... & Cappello, P. (2021). IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions. Proceedings of the National Academy of Sciences, 118(6), e2020395118.

Wu, M., Lai, T., Jing, D., Yang, S., Wu, Y., Li, Z., ... & Shen, H. (2021). Epithelium-derived IL17A Promotes Cigarette Smoke–induced Inflammation and Mucus Hyperproduction. American Journal of Respiratory Cell and Molecular Biology, 65(6), 581-592.

Pettas, E., Savva, V., Theofilou, V. I., Georgaki, M., & Nikitakis, N. G. (2021). Oral Candida infection in psoriatic patients treated with IL17A inhibitors: report of 3 cases and a comprehensive review of the literature. Diagnostics, 12(1), 3.

Johnson, D., Patel, A. B., Uemura, M. I., Trinh, V. A., Jackson, N., Zobniw, C. M., ... & Diab, A. (2019). IL17A blockade successfully treated psoriasiform dermatologic toxicity from immunotherapy. Cancer Immunology Research, 7(6), 860-865.

Armstrong, D., Chang, C. Y., Lazarus, D. R., Corry, D., & Kheradmand, F. (2019). Lung cancer heterogeneity in modulation of Th17/IL17A responses. Frontiers in Oncology, 9, 1384.

Hari, S. (2019). In silico molecular docking and ADME/T analysis of plant compounds against IL17A and IL18 targets in gouty arthritis. Journal of Applied Pharmaceutical Science, 9(7), 018-026.

Bao, L., Yin, J., Gao, W., Wang, Q., Yao, W., & Gao, X. (2018). A long‐acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non‐alcoholic steatohepatitis partly through an FGF21‐adiponectin‐IL17A pathway. British journal of pharmacology, 175(16), 3379-3393.

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For research use only. Not intended for any clinical use.

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