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Mouse Anti-IL17RD Recombinant Antibody (CBYY-I1350) (CBMAB-I2520-YY)

This product is Mouse antibody that recognizes IL17RD. The antibody CBYY-I1350 can be used for immunoassay techniques such as: ELISA, WB
See all IL17RD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I1350
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, pH 7.4, 5% trehalose
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 17 Receptor D
Introduction
This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms.
Entrez Gene ID
54756
UniProt ID
Q8NFM7
Alternative Names
Interleukin 17 Receptor D
Function
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12958313, PubMed:12807873).

Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK (PubMed:15239952).

Mediates JNK activation and may be involved in apoptosis (By similarity).

May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity).

Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).

Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Biological Process
Negative regulation of epithelial to mesenchymal transition Source: UniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Cellular Location
Golgi apparatus membrane; Cell membrane. Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.
Isoform 4: Cytoplasm
Involvement in disease
Hypogonadotropic hypogonadism 18 with or without anosmia (HH18):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Topology
Extracellular: 17-299
Helical: 300-320
Cytoplasmic: 321-739

Wang, Y., He, Y., Hu, X., Chi, Q., Zhao, B., Ye, J., & Li, S. (2022). Regulating of LncRNA2264/miR-20b-5p/IL17RD axis on hydrogen sulfide exposure-induced inflammation in broiler thymus by activating MYD88/NF-κB pathway. Toxicology, 467, 153086.

Khan, M. A., Zheng, M., Fu, J., Tania, M., Li, J., & Fu, J. (2022). Thymoquinone upregulates IL17RD in controlling the growth and metastasis of triple negative breast cancer cells in vitro. BMC cancer, 22(1), 1-11.

Fu, Y., Liu, S., Li, M., Ren, F., Wang, Y., & Chang, Z. (2022). IL‐17RD/sef exacerbates experimental mouse colitis and inflammation‐associated tumorigenesis by regulating the proportion of T cell subsets. FEBS letters, 596(4), 427-436.

Men, M., Wang, X., Wu, J., Zeng, W., Jiang, F., Zheng, R., & Li, J. D. (2021). Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism. Journal of medical genetics, 58(1), 66-72.

Peng, D. H., Kundu, S. T., Fradette, J. J., Diao, L., Tong, P., Byers, L. A., ... & Gibbons, D. L. (2019). ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism. Science translational medicine, 11(483), eaaq1238.

Qian, L., Guan, J., Wu, Y., & Wang, Q. (2019). Upregulated circular RNA circ_0074027 promotes glioblastoma cell growth and invasion by regulating miR-518a-5p/IL17RD signaling pathway. Biochemical and biophysical research communications, 510(4), 515-519.

Zhu, J., Zhang, Q., Jin, X. Y., Cai, J. B., Chen, X., Shi, W. B., ... & Yang, L. J. (2019). MiR-506 suppresses papillary thyroid carcinoma cell proliferation and metastasis via targeting IL17RD. European Review for Medical & Pharmacological Sciences, 23(7).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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