Human Recombinant IL17RD protein, His Tag (V2LY-0526-LY4787)

Name: Human Recombinant IL17RD protein, His Tag
SKU: V2LY-0526-LY4787
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant IL17RD protein, His Tag consist of Amino Acid: 1-299 and predicts a molecular mass of 33.5 kDa.

Molecule Mass

33.5 kDa

Sequence

Amino Acid: 1-299

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 17 Receptor D

Function

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12958313, PubMed:12807873).

Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK (PubMed:15239952).

Mediates JNK activation and may be involved in apoptosis (By similarity).

May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity).

Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).

Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

Biological Process

Negative regulation of epithelial to mesenchymal transition Source: UniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB

Cellular Location

Golgi apparatus membrane; Cell membrane. Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.
Isoform 4: Cytoplasm

Involvement in disease

Hypogonadotropic hypogonadism 18 with or without anosmia (HH18):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).

Topology

Extracellular: 17-299
Helical: 300-320
Cytoplasmic: 321-739

Wang, Y., He, Y., Hu, X., Chi, Q., Zhao, B., Ye, J., & Li, S. (2022). Regulating of LncRNA2264/miR-20b-5p/IL17RD axis on hydrogen sulfide exposure-induced inflammation in broiler thymus by activating MYD88/NF-κB pathway. Toxicology, 467, 153086.

Khan, M. A., Zheng, M., Fu, J., Tania, M., Li, J., & Fu, J. (2022). Thymoquinone upregulates IL17RD in controlling the growth and metastasis of triple negative breast cancer cells in vitro. BMC cancer, 22(1), 1-11.

Fu, Y., Liu, S., Li, M., Ren, F., Wang, Y., & Chang, Z. (2022). IL‐17RD/sef exacerbates experimental mouse colitis and inflammation‐associated tumorigenesis by regulating the proportion of T cell subsets. FEBS letters, 596(4), 427-436.

Men, M., Wang, X., Wu, J., Zeng, W., Jiang, F., Zheng, R., & Li, J. D. (2021). Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism. Journal of medical genetics, 58(1), 66-72.

Peng, D. H., Kundu, S. T., Fradette, J. J., Diao, L., Tong, P., Byers, L. A., ... & Gibbons, D. L. (2019). ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism. Science translational medicine, 11(483), eaaq1238.

Qian, L., Guan, J., Wu, Y., & Wang, Q. (2019). Upregulated circular RNA circ_0074027 promotes glioblastoma cell growth and invasion by regulating miR-518a-5p/IL17RD signaling pathway. Biochemical and biophysical research communications, 510(4), 515-519.

Zhu, J., Zhang, Q., Jin, X. Y., Cai, J. B., Chen, X., Shi, W. B., ... & Yang, L. J. (2019). MiR-506 suppresses papillary thyroid carcinoma cell proliferation and metastasis via targeting IL17RD. European Review for Medical & Pharmacological Sciences, 23(7).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IL17RD protein, hFc Tag (CAT#: V2LY-0526-LY1272)

Canine Recombinant IL17RD protein, His Tag (CAT#: V2LY-0526-LY1273)

Related Products

Canine Recombinant IL17RD protein, His Tag (CAT#: V2LY-0526-LY1273)

Canine Recombinant IL17RD protein, hFc Tag (CAT#: V2LY-0526-LY1272)

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Mouse Anti-IL17RD Recombinant Antibody (CBYY-I1350) (CAT#: CBMAB-I2520-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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