Sign in or Register   Sign in or Register
  |  

Rat Anti-IL1R1 Recombinant Antibody (12A6) (CBMAB-C2611-LY)

This product is antibody recognizes IL1R1. The antibody 12A6 immunoassay techniques such as: FC.
See all IL1R1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
12A6
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Immunogen
IL-1 receptors from the C57BL/6 mouse T lymphoma EL4.IL2
Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interleukin 1 Receptor Type 1
Introduction
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Entrez Gene ID
16177
UniProt ID
Q8C6P3
Function
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-1-mediated signaling pathway Source: BHF-UCL
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Positive regulation of neutrophil extravasation Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Regulation of inflammatory response Source: GO_Central
Response to interleukin-1 Source: BHF-UCL
Cellular Location
Cell membrane; Secreted; Membrane
Topology
Extracellular: 18-336
Helical: 337-356
Cytoplasmic: 357-569
PTM
A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.

Zhang, Y., Zhang, Z. T., Wan, S. Y., Yang, J., Wei, Y. J., Chen, H. J., ... & Huang, K. (2023). ANGPTL3 negatively regulates IL-1β-induced NF-κB activation by inhibiting the IL1R1-associated signaling complex assembly. Journal of Molecular Cell Biology, mjad053.

Mansour, H., Banaganapalli, B., Nasser, K. K., Al-Aama, J. Y., Shaik, N. A., Saadah, O. I., & Elango, R. (2022). Genome-wide association study-guided exome rare variant burden analysis identifies IL1R1 and CD3E as potential autoimmunity risk genes for celiac disease. Frontiers in Pediatrics, 10, 837957.

Umemura, T., Fujinaga, Y., Ashihara, N., Ozawa, M., Kuraishi, Y., Watanabe, T., ... & Ota, M. (2022). IL1R1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease. Gene, 820, 146212.

Sivaraj, N., Rachel, K. V., Suvvari, T. K., Prasad, S., Boppana, S. H., & Vegi, P. K. (2022). Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia. Journal of Reproductive Immunology, 149, 103463.

Akkaya-Ulum, Y. Z., Akbaba, T. H., Tavukcuoglu, Z., Chae, J. J., Yilmaz, E., Ozen, S., & Balci-Peynircioglu, B. (2021). Familial Mediterranean fever-related miR-197-3p targets IL1R1 gene and modulates inflammation in monocytes and synovial fibroblasts. Scientific reports, 11(1), 685.

Jiang, W., Wang, X., Gao, P., Li, F., Lu, K., Tan, X., ... & Wang, Y. (2021). Association of IL1R1 coding variant with plasma-level soluble ST2 and risk of aortic dissection. Frontiers in Cardiovascular Medicine, 8, 710425.

Zhang, M., Zeng, L., Peng, Y., Fan, B., Chen, P., & Liu, J. (2021). Immune-related genes LAMA2 and IL1R1 correlate with tumor sites and predict poor survival in pancreatic adenocarcinoma. Future Oncology, 17(23), 3061-3076.

Zhang, L., Chu, Q., Liu, X., & Xu, T. (2020). microRNA-21 negatively regulates NF-κB signaling pathway via targeting IL1R1 in miiuy croaker. Developmental & Comparative Immunology, 105, 103578.

Roshanzamir, N., & Hassan-Zadeh, V. (2020). Methylation of specific CpG sites in IL-1β and IL1R1 genes is affected by hyperglycaemia in type 2 diabetic patients. Immunological investigations, 49(3), 287-298.

Feng, X., Guan, D., Auen, T., Choi, J. W., Salazar Hernández, M. A., Lee, J., ... & Ozcan, U. (2019). IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects. Nature medicine, 25(4), 575-582.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-IL1R1 Recombinant Antibody (12A6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare