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IL1R1

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

Full Name

Interleukin 1 Receptor Type 1

Function

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-1-mediated signaling pathway Source: BHF-UCL
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Positive regulation of neutrophil extravasation Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Regulation of inflammatory response Source: GO_Central
Response to interleukin-1 Source: BHF-UCL

Cellular Location

Cell membrane; Secreted; Membrane

Topology

Extracellular: 18-336
Helical: 337-356
Cytoplasmic: 357-569

PTM

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.

Anti-IL1R1 antibodies

Rat Anti-IL1R1 Recombinant Antibody (CBFYA-0011) (CBMAB-X0016-FY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYA-0011

Application*: IA, IP, WB

Rat Anti-IL1R1 Recombinant Antibody (CBFYA-0010) (CBMAB-X0015-FY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBFYA-0010

Application*: FN, IA, IP, WB

Mouse Anti-IL1R1 Recombinant Antibody (CBWJC-3813) (CBMAB-C5082WJ)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJC-3813

Application*: E

Rat Anti-IL1R1 Recombinant Antibody (CBWJC-3812) (CBMAB-C5081WJ)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBWJC-3812

Application*: WB, FN

Rat Anti-IL1R1 Recombinant Antibody (CBWJC-3811) (CBMAB-C5080WJ)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBWJC-3811

Application*: WB

Mouse Anti-IL1R1 Recombinant Antibody (CBWJC-3810) (CBMAB-C5079WJ)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJC-3810

Application*: E, IC

Rat Anti-IL1R1 Recombinant Antibody (CBFYC-2757) (CBMAB-C2832-FY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBFYC-2757

Application*: F

Mouse Anti-IL1R1 Recombinant Antibody (CBYY-I1441) (CBMAB-I2611-YY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-I1441

Application*: E, IH, R

Mouse Anti-IL1R1 Recombinant Antibody (CBYY-I1383) (CBMAB-I2553-YY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-I1383

Application*: E

Rat Anti-IL1R1 Recombinant Antibody (CBYY-I1281) (CBMAB-I2450-YY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBYY-I1281

Application*: F

Rabbit Anti-IL1R1 Recombinant Antibody (CBYY-I1224) (CBMAB-I2393-YY)

SDS

Target: IL1R1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYY-I1224

Application*: E

Rat Anti-IL1R1 Recombinant Antibody (CBYY-I1144) (CBMAB-I2312-YY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBYY-I1144

Application*: N, WB

Mouse Anti-IL1R1 Recombinant Antibody (CBYY-I1095) (CBMAB-I2263-YY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1095

Application*: WB

Mouse Anti-IL1R1 Recombinant Antibody (732229) (CBMAB-I1618-YY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 732229

Application*: F, MC

Mouse Anti-IL1R1 Recombinant Antibody (CBYY-I0725) (CBMAB-I1617-YY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-I0725

Application*: WB

Rat Anti-IL1R1 Recombinant Antibody (6A573) (CBMAB-I1540-YY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 6A573

Application*: WB

Rat Anti-IL1R1 Recombinant Antibody (6A571) (CBMAB-I1539-YY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 6A571

Application*: IP, WB

Rat Anti-IL1R1 Recombinant Antibody (6A570) (CBMAB-I1538-YY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 6A570

Application*: E, WB, IP, N

Rat Anti-IL1R1 Recombinant Antibody (Reg21) (CBMAB-I1042-YY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: Reg21

Application*: WB, IP, I, R, FN

Hamster Anti-IL1R1 Recombinant Antibody (JAMA-147) (CBMAB-I0464-YY)

SDS

Target: IL1R1

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: JAMA-147

Application*: IP, FN, F, N, BL

Rat Anti-IL1R1 Recombinant Antibody (D1f3) (CBMAB-I0463-YY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: D1f3

Application*: E, IP, WB, I

Rat Anti-IL1R1 Recombinant Antibody (D14e3) (CBMAB-I0462-YY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: D14e3

Application*: WB

Rabbit Anti-IL1R1 Recombinant Antibody (CBYY-I0163) (CBMAB-I0461-YY)

SDS

Target: IL1R1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYY-I0163

Application*: F

Mouse Anti-IL1R1 Recombinant Antibody (CBYY-I0161) (CBMAB-I0459-YY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBYY-I0161

Application*: E, ED

Rabbit Anti-IL1R1 Recombinant Antibody (CBYY-I0160) (CBMAB-I0458-YY)

SDS

Target: IL1R1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat

Clone: CBYY-I0160

Application*: E, F

Rabbit Anti-IL1R1 Recombinant Antibody (7) (CBMAB-C8389-LY)

SDS

Target: IL1R1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat

Clone: 7

Application*: E

Rat Anti-IL1R1 Recombinant Antibody (12A6) (CBMAB-C2611-LY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: 12A6

Application*: F

Mouse Anti-IL1R1 Recombinant Antibody (A521) (CBMAB-AP3928LY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG

Specificity: Monkey

Clone: A521

Application*: ICC, IHC, IP, WB

Mouse Anti-IL1R1 Recombinant Antibody (A520) (CBMAB-AP3926LY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG

Specificity: Rabbit

Clone: A520

Application*: ICC, IHC, IP, WB

Recombinant Rat Anti-IL1R1 Antibody (CBHb018) (CBMAB-Hb573-LY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBHb018

Application*: WB

Recombinant Rat Anti-IL1R1 Antibody (CBHb017) (CBMAB-Hb572-LY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBHb017

Application*: FuncS, WB

Recombinant Rat Anti-IL1R1 Antibody (CBHb016) (CBMAB-Hb570-LY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBHb016

Application*: Immuno assays, IP, WB

Recombinant Rat Anti-IL1R1 Antibody (CBHb015) (CBMAB-Hb571-LY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBHb015

Application*: FuncS, Immuno assays, IP, WB

Mouse Anti-IL1R1 Recombinant Antibody (BDI204) (CBMAB-C3599-CN)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: BDI204

Application*: E, IF, R

Rabbit Anti-IL1R1 Recombinant Antibody (CBYY-C2560) (CBMAB-C4001-YY)

SDS

Target: IL1R1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat

Clone: CBYY-C2560

Application*: E

Mouse Anti-IL1R1 Recombinant Antibody (CBYY-C2559) (CBMAB-C4000-YY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C2559

Application*: E, IF, P, IA

Rat Anti-IL1R1 Recombinant Antibody (CBYY-C0042) (CBMAB-C0118-YY)

SDS

Target: IL1R1

Host: Rat

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: CBYY-C0042

Application*: F

Mouse Anti-IL1R1 Recombinant Antibody (35730 (49/20)) (CBMAB-C0114-YY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 35730 (49/20)

Application*: WB, E

Mouse Anti-IL1R1 Recombinant Antibody (40101) (CBMAB-C6434-LY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 40101

Application*: E, IC/IF, P, R

Mouse Anti-IL1R1 Recombinant Antibody (35732.45) (CBMAB-C1379-LY)

SDS

Target: IL1R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 35732.45

Application*: WB, E

Armenian Hamster Anti-IL-1R Recombinant Antibody (JAMA-147) (CBMAB-1026-LY)

SDS

Target: IL1R1

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: JAMA-147

Application*: B

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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