IL1R1
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Full Name
Interleukin 1 Receptor Type 1
Function
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-1-mediated signaling pathway Source: BHF-UCL
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Positive regulation of neutrophil extravasation Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Regulation of inflammatory response Source: GO_Central
Response to interleukin-1 Source: BHF-UCL
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-1-mediated signaling pathway Source: BHF-UCL
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Positive regulation of neutrophil extravasation Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Regulation of inflammatory response Source: GO_Central
Response to interleukin-1 Source: BHF-UCL
Cellular Location
Cell membrane; Secreted; Membrane
Topology
Extracellular: 18-336
Helical: 337-356
Cytoplasmic: 357-569
Helical: 337-356
Cytoplasmic: 357-569
PTM
A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
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Anti-IL1R1 antibodies
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CompareTarget: IL1R1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: BDI204
Application*: E, IF, R
Target: IL1R1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBFYC-2757
Application*: F
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 6A573
Application*: WB
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG
Specificity: Monkey
Clone: A521
Application*: ICC, IHC, IP, WB
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rabbit
Clone: A520
Application*: ICC, IHC, IP, WB
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBHb018
Application*: WB
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBHb017
Application*: FuncS, WB
Target: IL1R1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBHb016
Application*: Immuno assays, IP, WB
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBHb015
Application*: FuncS, Immuno assays, IP, WB
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-C0042
Application*: F
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 35730 (49/20)
Application*: WB, E
Target: IL1R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 7
Application*: E
Target: IL1R1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 12A6
Application*: F
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 26F8
Application*: E, F
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3300
Application*: WB, F
Target: IL1R1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0011
Application*: IA, IP, WB
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYA-0010
Application*: FN, IA, IP, WB
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-3813
Application*: E
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-3812
Application*: WB, FN
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-3811
Application*: WB
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3810
Application*: E, IC
Target: IL1R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYY-C2560
Application*: E
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2559
Application*: E, IF, P, IA
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1441
Application*: E, IH, R
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1383
Application*: E
Target: IL1R1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I1281
Application*: F
Target: IL1R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-I1224
Application*: E
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I1144
Application*: N, WB
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1095
Application*: WB
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 732229
Application*: F, MC
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0725
Application*: WB
Target: IL1R1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6A571
Application*: IP, WB
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 6A570
Application*: E, WB, IP, N
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: Reg21
Application*: WB, IP, I, R, FN
Target: IL1R1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: JAMA-147
Application*: IP, FN, F, N, BL
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: D1f3
Application*: E, IP, WB, I
Target: IL1R1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: D14e3
Application*: WB
Target: IL1R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-I0163
Application*: F
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-I0161
Application*: E, ED
Target: IL1R1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYY-I0160
Application*: E, F
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 40101
Application*: E, IC/IF, P, R
Target: IL1R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 35732.45
Application*: WB, E
Target: IL1R1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: JAMA-147
Application*: B
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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