Rat Anti-IL1R1 Recombinant Antibody (CBYY-I1144) (CBMAB-I2312-YY)

Name: Rat Anti-IL1R1 Recombinant Antibody (CBYY-I1144)
SKU: CBMAB-I2312-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYY-I1144

Application

N, WB

Specificity

Mouse

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA

Preservative

0.02% sodium azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interleukin 1 Receptor Type 1

Introduction

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12.

Entrez Gene ID

16177

UniProt ID

Q8C6P3

Alternative Names

Interleukin 1 Receptor Type 1

Function

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-1-mediated signaling pathway Source: BHF-UCL
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-1-mediated signaling pathway Source: Ensembl
Positive regulation of neutrophil extravasation Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Regulation of inflammatory response Source: GO_Central
Response to interleukin-1 Source: BHF-UCL

Cellular Location

Cell membrane; Secreted; Membrane

Topology

Extracellular: 18-336
Helical: 337-356
Cytoplasmic: 357-569

PTM

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.

Zhang, Y., Zhang, Z. T., Wan, S. Y., Yang, J., Wei, Y. J., Chen, H. J., ... & Huang, K. (2023). ANGPTL3 negatively regulates IL-1β-induced NF-κB activation by inhibiting the IL1R1-associated signaling complex assembly. Journal of Molecular Cell Biology, mjad053.

Mansour, H., Banaganapalli, B., Nasser, K. K., Al-Aama, J. Y., Shaik, N. A., Saadah, O. I., & Elango, R. (2022). Genome-wide association study-guided exome rare variant burden analysis identifies IL1R1 and CD3E as potential autoimmunity risk genes for celiac disease. Frontiers in Pediatrics, 10, 837957.

Umemura, T., Fujinaga, Y., Ashihara, N., Ozawa, M., Kuraishi, Y., Watanabe, T., ... & Ota, M. (2022). IL1R1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease. Gene, 820, 146212.

Sivaraj, N., Rachel, K. V., Suvvari, T. K., Prasad, S., Boppana, S. H., & Vegi, P. K. (2022). Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia. Journal of Reproductive Immunology, 149, 103463.

Akkaya-Ulum, Y. Z., Akbaba, T. H., Tavukcuoglu, Z., Chae, J. J., Yilmaz, E., Ozen, S., & Balci-Peynircioglu, B. (2021). Familial Mediterranean fever-related miR-197-3p targets IL1R1 gene and modulates inflammation in monocytes and synovial fibroblasts. Scientific reports, 11(1), 685.

Jiang, W., Wang, X., Gao, P., Li, F., Lu, K., Tan, X., ... & Wang, Y. (2021). Association of IL1R1 coding variant with plasma-level soluble ST2 and risk of aortic dissection. Frontiers in Cardiovascular Medicine, 8, 710425.

Zhang, M., Zeng, L., Peng, Y., Fan, B., Chen, P., & Liu, J. (2021). Immune-related genes LAMA2 and IL1R1 correlate with tumor sites and predict poor survival in pancreatic adenocarcinoma. Future Oncology, 17(23), 3061-3076.

Zhang, L., Chu, Q., Liu, X., & Xu, T. (2020). microRNA-21 negatively regulates NF-κB signaling pathway via targeting IL1R1 in miiuy croaker. Developmental & Comparative Immunology, 105, 103578.

Roshanzamir, N., & Hassan-Zadeh, V. (2020). Methylation of specific CpG sites in IL-1β and IL1R1 genes is affected by hyperglycaemia in type 2 diabetic patients. Immunological investigations, 49(3), 287-298.

Feng, X., Guan, D., Auen, T., Choi, J. W., Salazar Hernández, M. A., Lee, J., ... & Ozcan, U. (2019). IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects. Nature medicine, 25(4), 575-582.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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