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Mouse Anti-IL1RAPL1 Recombinant Antibody (1C10) (CBMAB-A4382-LY)

The product is antibody recognizes IL1RAPL1. The antibody 1C10 immunoassay techniques such as: WB, ELISA.
See all IL1RAPL1 antibodies
Published Data
Fig. 1 Anti-IL1RAPL1 antibody was used to quantify the expression of IL1RAPL1 in hippocampal neurons by immunofluorescence.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
IL1RAPL1 (NP_055086.1, 151 a.a. ~ 250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
interleukin 1 receptor accessory protein-like 1
Introduction
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq]
Entrez Gene ID
11141
UniProt ID
Q9NZN1
Alternative Names
IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2
Function
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849).

May activate the MAP kinase JNK (PubMed:15123616).

Plays a role in neurite outgrowth (By similarity).

During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
Biological Process
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
Negative regulation of exocytosis Source: UniProtKB
Neuron differentiation Source: BHF-UCL
Positive regulation of dendrite morphogenesis Source: BHF-UCL
Positive regulation of synapse assembly Source: UniProtKB
Presynaptic membrane assembly Source: BHF-UCL
Regulation of neuron projection development Source: UniProtKB
Regulation of postsynapse organization Source: SynGO
Regulation of presynapse assembly Source: SynGO
Signal transduction Source: InterPro
Trans-synaptic signaling by trans-synaptic complex Source: SynGO
Cellular Location
Cell membrane; Cytoplasm; Axon; Dendrite. May localize to the cell body and growth cones of dendrite-like processes.
Involvement in disease
Intellectual developmental disorder, X-linked 21 (XLID21):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
Topology
Extracellular: 19-357
Helical: 358-378
Cytoplasmic: 379-696

Weaver, J. (2023). The Genomics of Autism-Related Genes IL1RAPL1 and IL1RAPL2: Insights into Their Cortical Distribution, Cell-Type Specificity, and Developmental Trajectories.

Kanwal, A., Pardo, J. V., & Naz, S. (2022). RGS3 and IL1RAPL1 missense variants implicate defective neurotransmission in early-onset inherited schizophrenias. Journal of Psychiatry and Neuroscience, 47(6), E379-E390.

Holden, K., Rath, P., Drydale, E., Bancroft, J., & Handunnetthi, L. (2022). CRISPR/Cas9-mediated knockout of IL1RAPL1 in stem cells highlights a role in neural cell migration during cortical development.

Jiang, E., Fitzgerald, M. P., Helbig, K. L., & Goldberg, E. M. (2021). IL1RAPL1 Gene deletion in a female patient with developmental delay and continuous spike-wave during sleep. Journal of Pediatric Epilepsy, 11(01), 021-026.

Yuan, F., Wang, S., Wang, Y., Wang, A., Wang, C., Luo, X., ... & Chen, Y. (2021). Generation and characterization of the induced pluripotent stem cell line SHCDNi004-A from a ten-year-old Chinese boy with X-linked mental retardation in IL1RAPL1 deficiency. Stem Cell Research, 53, 102292.

Montani, C., Gritti, L., Beretta, S., Verpelli, C., & Sala, C. (2019). The synaptic and neuronal functions of the X‐linked intellectual disability protein interleukin‐1 receptor accessory protein like 1 (IL1RAPL1). Developmental neurobiology, 79(1), 85-95.

Ponzoni, L., Sala, C., Verpelli, C., Sala, M., & Braida, D. (2019). Different attentional dysfunctions in eEF2K−/−, IL1RAPL1−/− and SHANK3Δ11−/− mice. Genes, Brain and Behavior, 18(5), e12563.

Sun, Z., & Chadwick, B. P. (2018). Loss of SETDB1 decompacts the inactive X chromosome in part through reactivation of an enhancer in the IL1RAPL1 gene. Epigenetics & chromatin, 11(1), 1-20.

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For research use only. Not intended for any clinical use.

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