Mouse Anti-IL1RAPL1 Recombinant Antibody (CBT4386) (V2LY-0625-LY424)

Name: Mouse Anti-IL1RAPL1 Recombinant Antibody (CBT4386)
SKU: V2LY-0625-LY424
Rating: 5 (1 reviews)

See all IL1RAPL1 antibodies

Compare Online Inquiry

Tested Data

Mouse Anti-IL1RAPL1 Recombinant Antibody (CBT4386) (V2LY-0625-LY424) in ELISA

Mouse Anti-IL1RAPL1 Recombinant Antibody (CBT4386) (V2LY-0625-LY424) in WB

Mouse Anti-IL1RAPL1 Recombinant Antibody (CBT4386) (V2LY-0625-LY424) in IF

Mouse Anti-IL1RAPL1 Recombinant Antibody (CBT4386) (V2LY-0625-LY424) in FC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4386

Application

WB, ICC, FC

Immunogen

Purified recombinant fragment of human IL1RAPL1 (AA: 541-694) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ICC	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

interleukin 1 receptor accessory protein-like 1

Entrez Gene ID

11141

UniProt ID

Q9NZN1

Function

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849).

May activate the MAP kinase JNK (PubMed:15123616).

Plays a role in neurite outgrowth (By similarity).

During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).

Biological Process

Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
Negative regulation of exocytosis Source: UniProtKB
Neuron differentiation Source: BHF-UCL
Positive regulation of dendrite morphogenesis Source: BHF-UCL
Positive regulation of synapse assembly Source: UniProtKB
Presynaptic membrane assembly Source: BHF-UCL
Regulation of neuron projection development Source: UniProtKB
Regulation of postsynapse organization Source: SynGO
Regulation of presynapse assembly Source: SynGO
Signal transduction Source: InterPro
Trans-synaptic signaling by trans-synaptic complex Source: SynGO

Cellular Location

Cell membrane; Cytoplasm; Axon; Dendrite. May localize to the cell body and growth cones of dendrite-like processes.

Involvement in disease

Intellectual developmental disorder, X-linked 21 (XLID21):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.

Topology

Extracellular: 19-357
Helical: 358-378
Cytoplasmic: 379-696

Weaver, J. (2023). The Genomics of Autism-Related Genes IL1RAPL1 and IL1RAPL2: Insights into Their Cortical Distribution, Cell-Type Specificity, and Developmental Trajectories.

Kanwal, A., Pardo, J. V., & Naz, S. (2022). RGS3 and IL1RAPL1 missense variants implicate defective neurotransmission in early-onset inherited schizophrenias. Journal of Psychiatry and Neuroscience, 47(6), E379-E390.

Holden, K., Rath, P., Drydale, E., Bancroft, J., & Handunnetthi, L. (2022). CRISPR/Cas9-mediated knockout of IL1RAPL1 in stem cells highlights a role in neural cell migration during cortical development.

Jiang, E., Fitzgerald, M. P., Helbig, K. L., & Goldberg, E. M. (2021). IL1RAPL1 Gene deletion in a female patient with developmental delay and continuous spike-wave during sleep. Journal of Pediatric Epilepsy, 11(01), 021-026.

Yuan, F., Wang, S., Wang, Y., Wang, A., Wang, C., Luo, X., ... & Chen, Y. (2021). Generation and characterization of the induced pluripotent stem cell line SHCDNi004-A from a ten-year-old Chinese boy with X-linked mental retardation in IL1RAPL1 deficiency. Stem Cell Research, 53, 102292.

Montani, C., Gritti, L., Beretta, S., Verpelli, C., & Sala, C. (2019). The synaptic and neuronal functions of the X‐linked intellectual disability protein interleukin‐1 receptor accessory protein like 1 (IL1RAPL1). Developmental neurobiology, 79(1), 85-95.

Ponzoni, L., Sala, C., Verpelli, C., Sala, M., & Braida, D. (2019). Different attentional dysfunctions in eEF2K−/−, IL1RAPL1−/− and SHANK3Δ11−/− mice. Genes, Brain and Behavior, 18(5), e12563.

Sun, Z., & Chadwick, B. P. (2018). Loss of SETDB1 decompacts the inactive X chromosome in part through reactivation of an enhancer in the IL1RAPL1 gene. Epigenetics & chromatin, 11(1), 1-20.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-IL1RAPL1 Recombinant Antibody (CBT4386)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-IL1RAPL1 Recombinant Antibody (1C10) (CAT#: CBMAB-A4382-LY)

Mouse Anti-IL1RAPL1 Recombinant Antibody (CBYY-I0165) (CAT#: CBMAB-I0467-YY)

Mouse Anti-IL1RAPL1 Recombinant Antibody (CBT4459) (CAT#: V2LY-0625-LY425)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry