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Mouse Anti-IL1RL1 Recombinant Antibody (CBXS-1994) (CBMAB-S4762-CQ)

This product is a mouse antibody that recognizes IL1RL1. The antibody CBXS-1994 can be used for immunoassay techniques such as: WB, Neut, ELISA(Cap).
See all IL1RL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1994
Antibody Isotype
IgG1
Application
WB, Neut, ELISA(Cap)

Basic Information

Immunogen
Sf 21-derived recombinant human ST2/IL-33 R, Lys19-Phe328, Accession # BAA02233
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 1 Receptor Like 1
Introduction
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
9173
UniProt ID
Q01638
Alternative Names
Interleukin 1 Receptor Like 1
Function
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

Isoform B
Inhibits IL-33 signaling.
Cellular Location
Isoform C: Cell membrane
Isoform B: Secreted; Cell membrane
Topology
Extracellular: 19-328
Helical: 329-349
Cytoplasmic: 350-556

Jiang, Y., Zhou, X., Wong, H. Y., Ouyang, L., Ip, F. C., Chau, V. M., ... & Ip, N. Y. (2022). An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease. Nature aging, 2(7), 616-634.

Li, Z., Ren, J., Zhang, J., Wang, X., Liu, Y., & Wang, Q. (2022). Association between IL1RL1 gene polymorphisms and allergic rhinitis risk in the Chinese Han population. Journal of Clinical Laboratory Analysis, 36(11), e24747.

Yu, G. I., Song, D. K., & Shin, D. H. (2020). Associations of IL1RAP and IL1RL1 gene polymorphisms with obesity and inflammation mediators. Inflammation Research, 69, 191-202.

Fulgione, A., Papaianni, M., Cuomo, P., Paris, D., Romano, M., Tuccillo, C., ... & Capparelli, R. (2020). Interaction between MyD88, TIRAP and IL1RL1 against Helicobacter pylori infection. Scientific reports, 10(1), 15831.

Dijk, F. N., Vijverberg, S. J., Hernandez‐Pacheco, N., Repnik, K., Karimi, L., Mitratza, M., ... & Koppelman, G. H. (2020). IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids. Allergy, 75(4), 984.

Wang, Y., Luo, H., Wei, M., Becker, M., Hyde, R. K., & Gong, Q. (2020). IL-33/IL1RL1 axis regulates cell survival through the p38 MAPK pathway in acute myeloid leukemia. Leukemia Research, 96, 106409.

Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., ... & Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8).

Ahmadi, M., Fathi, F., Fouladi, S., Alsahebfosul, F., Manian, M., & Eskandari, N. (2019). Serum IL-33 level and IL-33, IL1RL1 gene polymorphisms in asthma and multiple sclerosis patients. Current Molecular Medicine, 19(5), 357-363.

Schaunaman, N., Sanchez, A., Dimasuay, K. G., Pavelka, N., Numata, M., Alam, R., ... & Chu, H. W. (2019). Interleukin 1 receptor-like 1 (IL1RL1) promotes airway bacterial and viral infection and inflammation. Infection and immunity, 87(7), 10-1128.

Dijk, F. N., Xu, C., Melén, E., Carsin, A. E., Kumar, A., Nolte, I. M., ... & Koppelman, G. H. (2018). Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma. European Respiratory Journal, 51(3).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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