IL1RL1
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.
Full Name
Interleukin 1 Receptor Like 1
Function
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
Isoform B
Inhibits IL-33 signaling.
Isoform B
Inhibits IL-33 signaling.
Cellular Location
Isoform C: Cell membrane
Isoform B: Secreted; Cell membrane
Isoform B: Secreted; Cell membrane
Topology
Extracellular: 19-328
Helical: 329-349
Cytoplasmic: 350-556
Helical: 329-349
Cytoplasmic: 350-556
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Anti-IL1RL1 antibodies
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CompareTarget: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: S7B7
Application*: E
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HB12
Application*: F, IH, IP, WB
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: FB9
Application*: E, F, IP, WB
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2594
Application*: N, WB
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1994
Application*: WB, N, EC
Target: IL1RL1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-1727
Application*: WB
Target: IL1RL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1705
Application*: WB
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B-L42
Application*: F, WB
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B-D52
Application*: E
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-A52
Application*: E
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-5551
Application*: E, WB
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXS-5206
Application*: WB, N
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4352
Application*: F, IP, WB
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B4E6
Application*: F, IH
Target: IL1RL1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-1726
Application*: F
Target: IL1RL1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-1391
Application*: F, IP
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Chicken
Clone: CBYJT-1389
Application*: F, IP
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1833
Application*: F
Target: IL1RL1
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-I1700
Application*: F, BL
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig, Rat
Clone: CBYY-I1230
Application*: E, WB, IH
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ST33868
Application*: E, WB
Target: IL1RL1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBYY-I0453
Application*: F, FN
Target: IL1RL1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I0452
Application*: F
Target: IL1RL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A5
Application*: F, IP, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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