Human Recombinant IL1RL1 protein, His Tag (V2LY-0526-LY6956)

Name: Human Recombinant IL1RL1 protein, His Tag
SKU: V2LY-0526-LY6956
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant IL1RL1 protein, His Tag consist of Amino Acid: 1-328 and predicts a molecular mass of 36.5 kDa.

Molecule Mass

36.5 kDa

Verified

HPLC

Sequence

Amino Acid: 1-328

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 1 Receptor Like 1

Function

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

Isoform B
Inhibits IL-33 signaling.

Cellular Location

Isoform C: Cell membrane
Isoform B: Secreted; Cell membrane

Topology

Extracellular: 19-328
Helical: 329-349
Cytoplasmic: 350-556

Jiang, Y., Zhou, X., Wong, H. Y., Ouyang, L., Ip, F. C., Chau, V. M., ... & Ip, N. Y. (2022). An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease. Nature aging, 2(7), 616-634.

Li, Z., Ren, J., Zhang, J., Wang, X., Liu, Y., & Wang, Q. (2022). Association between IL1RL1 gene polymorphisms and allergic rhinitis risk in the Chinese Han population. Journal of Clinical Laboratory Analysis, 36(11), e24747.

Yu, G. I., Song, D. K., & Shin, D. H. (2020). Associations of IL1RAP and IL1RL1 gene polymorphisms with obesity and inflammation mediators. Inflammation Research, 69, 191-202.

Fulgione, A., Papaianni, M., Cuomo, P., Paris, D., Romano, M., Tuccillo, C., ... & Capparelli, R. (2020). Interaction between MyD88, TIRAP and IL1RL1 against Helicobacter pylori infection. Scientific reports, 10(1), 15831.

Dijk, F. N., Vijverberg, S. J., Hernandez‐Pacheco, N., Repnik, K., Karimi, L., Mitratza, M., ... & Koppelman, G. H. (2020). IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids. Allergy, 75(4), 984.

Wang, Y., Luo, H., Wei, M., Becker, M., Hyde, R. K., & Gong, Q. (2020). IL-33/IL1RL1 axis regulates cell survival through the p38 MAPK pathway in acute myeloid leukemia. Leukemia Research, 96, 106409.

Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., ... & Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8).

Ahmadi, M., Fathi, F., Fouladi, S., Alsahebfosul, F., Manian, M., & Eskandari, N. (2019). Serum IL-33 level and IL-33, IL1RL1 gene polymorphisms in asthma and multiple sclerosis patients. Current Molecular Medicine, 19(5), 357-363.

Schaunaman, N., Sanchez, A., Dimasuay, K. G., Pavelka, N., Numata, M., Alam, R., ... & Chu, H. W. (2019). Interleukin 1 receptor-like 1 (IL1RL1) promotes airway bacterial and viral infection and inflammation. Infection and immunity, 87(7), 10-1128.

Dijk, F. N., Xu, C., Melén, E., Carsin, A. E., Kumar, A., Nolte, I. M., ... & Koppelman, G. H. (2018). Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma. European Respiratory Journal, 51(3).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IL1RL1 protein, His Tag (CAT#: V2LY-0526-LY1646)

Cynomolgus Recombinant IL1RL1 protein, His Tag-1 (CAT#: V2LY-0526-LY1647)

Human Recombinant IL1RL1 protein (CAT#: V2LY-0526-LY6952)

Human Recombinant IL1RL1 protein-1 (CAT#: V2LY-0526-LY6954)

Human Recombinant IL1RL1 protein, hFc Tag (CAT#: V2LY-0526-LY6955)

Human Recombinant IL1RL1 (isoform a) protein, His Tag (CAT#: V2LY-0526-LY6957)

Mouse Recombinant IL1RL1 protein, hFc Tag (CAT#: V2LY-0526-LY8938)

Mouse Recombinant IL1RL1 protein, His Tag (CAT#: V2LY-0526-LY8939)

Human IL1RL1 ELISA Kit (CAT#: V2LY-0626-LY4708)

Mouse Il1rl1 ELISA Kit (CAT#: V2LY-0626-LY5820)

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Human Recombinant IL1RL1 (isoform a) protein, His Tag (CAT#: V2LY-0526-LY6957)

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Cynomolgus Recombinant IL1RL1 protein, His Tag (CAT#: V2LY-0526-LY1646)

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Human Recombinant IL1RL1 protein (CAT#: V2LY-0526-LY6952)

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Isotype control

For research use only. Not intended for any clinical use.

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